Literature DB >> 22923732

The functional roles of S1P in immunity.

Yu Hisano1, Tsuyoshi Nishi, Atsuo Kawahara.   

Abstract

The lipid mediator sphingosine-1-phosphate (S1P) is generated within cells from sphingosine by two sphingosine kinases (SPHK1 and SPHK2). Intracellularly synthesized S1P is released into the extracellular fluid by S1P transporters, including SPNS2. Released S1P binds specifically to the G protein-coupled S1P receptors (S1PR1/S1P(1)-S1PR5/S1P(5)), which activate a diverse range of downstream signalling pathways. Recent studies have proposed that one of the central physiological functions of intercellular S1P signalling is in lymphocyte trafficking in vivo because genetic disruption of SPHK1/2, SPNS2 or S1PR1/S1P(1) in mice induces a lymphopenia phenotype. In this review, we discuss the current understanding of intercellular S1P signalling in the context of immunity.

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Year:  2012        PMID： 22923732     DOI： 10.1093/jb/mvs090

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  27 in total

1.  Granule-mediated release of sphingosine-1-phosphate by activated platelets.

Authors:  Deepa Jonnalagadda; Manjula Sunkara; Andrew J Morris; Sidney W Whiteheart
Journal:  Biochim Biophys Acta       Date:  2014-08-23

2.  Maternal and Zygotic Sphingosine Kinase 2 Are Indispensable for Cardiac Development in Zebrafish.

Authors:  Yu Hisano; Asuka Inoue; Michiyo Okudaira; Kiyohito Taimatsu; Hirotaka Matsumoto; Hirohito Kotani; Rie Ohga; Junken Aoki; Atsuo Kawahara
Journal:  J Biol Chem       Date:  2015-04-23       Impact factor: 5.157

3.  T-Cell Depletion in the Colonic Mucosa of Patients With Idiopathic CD4+ Lymphopenia.

Authors:  Stephen B Kovacs; Virginia Sheikh; William L Thompson; David R Morcock; Ainhoa Perez-Diez; Michael D Yao; Adam W Rupert; Netanya S Utay; Gregg Roby; Alexandra F Freeman; Jacob D Estes; Irini Sereti
Journal:  J Infect Dis       Date:  2015-05-20       Impact factor: 5.226

4.  Knockout of Sphingosine Kinase 1 Attenuates Renal Fibrosis in Unilateral Ureteral Obstruction Model.

Authors:  Xiwen Zhang; Weili Wang; Xin-Ying Ji; Joseph K Ritter; Ningjun Li
Journal:  Am J Nephrol       Date:  2019-08-15       Impact factor: 3.754

5.  Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production.

Authors:  Se Kyoo Jeong; Young Il Kim; Kyong-Oh Shin; Bong-Woo Kim; Sin Hee Lee; Jeong Eun Jeon; Hyun Jong Kim; Yong-Moon Lee; Theodora M Mauro; Peter M Elias; Yoshikazu Uchida; Kyungho Park
Journal:  J Dermatol Sci       Date:  2015-06-19       Impact factor: 4.563

6.  SPHK-2 Promotes the Particle-Induced Inflammation of RAW264.7 by Maintaining Consistent Expression of TNF-α and IL-6.

Authors:  Guangpu Yang; Minghui Gu; Weishen Chen; Wenhua Liu; Yinbo Xiao; Haixing Wang; Weiming Lai; Guoyan Xian; Ziji Zhang; Ziqing Li; Puyi Sheng
Journal:  Inflammation       Date:  2018-08       Impact factor: 4.092

Review 7.  Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair.

Authors:  Ziad Sartawi; Ernestina Schipani; Katie B Ryan; Christian Waeber
Journal:  Pharmacol Res       Date:  2017-09-22       Impact factor: 7.658

8.  Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages.

Authors:  Philipp Burow; Manuela Klapperstück; Fritz Markwardt
Journal:  Pflugers Arch       Date:  2014-06-26       Impact factor: 3.657

9.  Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes.

Authors:  Naoki Kobayashi; Masato Otsuka; Akihito Yamaguchi; Tsuyoshi Nishi
Journal:  J Lipid Res       Date:  2016-09-21       Impact factor: 5.922

Review 10.  Bioactive lysolipids in cancer and angiogenesis.

Authors:  Yu Hisano; Timothy Hla
Journal:  Pharmacol Ther       Date:  2018-07-23       Impact factor: 12.310
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