BACKGROUND: Nowadays it seems that chronic kidney disease (CKD) is outbreaking, mostly in the elderly participants. The aim of this study was to assess the progression of CKD in different ages. METHODS: We conducted a monocentric, retrospective, observational study enrolling 116 patients afferent to our outpatient clinic. INCLUSION CRITERIA: age >18 years, follow-up ≥5 years, estimated glomerular filtration rate (eGFR) <60mL/min/1.73 m(2), and/or diagnosed renal disease and/or presence of renal damage. Patients were divided into four groups according to their age: 25-55 years (n = 27), 56-65 (25), 66-75 (42), and 76-87 (22). eGFR was calculated using the modification of diet in renal disease and the CKD-epidemiology collaboration formulas. RESULTS: Younger patients had a significantly longer follow-up and less comorbidities, evaluated by the cumulative illness rating scale score, compared with the other groups. There was no difference between creatinine at baseline and at the end-of-follow-up period among the groups. Even though renal function significantly decreased in all groups, we noticed a slower progression as the age increased, and the difference between basal and end-of-follow-up eGFR was minimal in the group of patients aged 76-87 years. Analyzing the eGFR of every ambulatory control plotted against the year of follow-up, we showed a more rapid loss of filtrate in the younger group. Instead, loss of renal function decreased as the age of patients increased. CONCLUSIONS: This study demonstrates that, in elderly Italian participants, progression of CKD occurs more slowly than in younger patients. This implies that we may probably face an epidemic of CKD but that most of elderly patients diagnosed with CKD may not evolve to end-stage renal disease and require renal replacement therapy.
BACKGROUND: Nowadays it seems that chronic kidney disease (CKD) is outbreaking, mostly in the elderly participants. The aim of this study was to assess the progression of CKD in different ages. METHODS: We conducted a monocentric, retrospective, observational study enrolling 116 patients afferent to our outpatient clinic. INCLUSION CRITERIA: age >18 years, follow-up ≥5 years, estimated glomerular filtration rate (eGFR) <60mL/min/1.73 m(2), and/or diagnosed renal disease and/or presence of renal damage. Patients were divided into four groups according to their age: 25-55 years (n = 27), 56-65 (25), 66-75 (42), and 76-87 (22). eGFR was calculated using the modification of diet in renal disease and the CKD-epidemiology collaboration formulas. RESULTS: Younger patients had a significantly longer follow-up and less comorbidities, evaluated by the cumulative illness rating scale score, compared with the other groups. There was no difference between creatinine at baseline and at the end-of-follow-up period among the groups. Even though renal function significantly decreased in all groups, we noticed a slower progression as the age increased, and the difference between basal and end-of-follow-up eGFR was minimal in the group of patients aged 76-87 years. Analyzing the eGFR of every ambulatory control plotted against the year of follow-up, we showed a more rapid loss of filtrate in the younger group. Instead, loss of renal function decreased as the age of patients increased. CONCLUSIONS: This study demonstrates that, in elderly Italian participants, progression of CKD occurs more slowly than in younger patients. This implies that we may probably face an epidemic of CKD but that most of elderly patients diagnosed with CKD may not evolve to end-stage renal disease and require renal replacement therapy.
Authors: Agnieszka Perkowska-Ptasinska; Dominika Deborska-Materkowska; Artur Bartczak; Tomasz Stompor; Tomasz Liberek; Barbara Bullo-Piontecka; Anna Wasinska; Agnieszka Serwacka; Marian Klinger; Jolanta Chyl; Michal Kuriga; Robert Malecki; Krzysztof Marczewski; Bogdan Hryniewicz; Tadeusz Gregorczyk; Monika Wieliczko; Stanislaw Niemczyk; Olga Rostkowska; Leszek Paczek; Magdalena Durlik Journal: BMC Nephrol Date: 2016-11-25 Impact factor: 2.388
Authors: Regina C R M Abdulkader; Emmanuel A Burdmann; Maria Lúcia Lebrão; Yeda A O Duarte; Dirce M T Zanetta Journal: PLoS One Date: 2017-12-19 Impact factor: 3.240
Authors: Andrea Corsonello; Lisanne Tap; Regina Roller-Wirnsberger; Gerhard Wirnsberger; Carmine Zoccali; Tomasz Kostka; Agnieszka Guligowska; Francesco Mattace-Raso; Pedro Gil; Lara Guardado Fuentes; Itshak Meltzer; Ilan Yehoshua; Francesc Formiga-Perez; Rafael Moreno-González; Christian Weingart; Ellen Freiberger; Johan Ärnlöv; Axel C Carlsson; Silvia Bustacchini; Fabrizia Lattanzio Journal: BMC Nephrol Date: 2018-10-11 Impact factor: 2.388
Authors: Andrea Corsonello; Regina Roller-Wirnsberger; Gerhard Wirnsberger; Johan Ärnlöv; Axel C Carlsson; Lisanne Tap; Francesco Mattace-Raso; Francesc Formiga; Rafael Moreno-Gonzalez; Christian Weingart; Cornel Sieber; Tomasz Kostka; Agnieszka Guligowska; Pedro Gil; Sara Lainez Martinez; Rada Artzi-Medvedik; Itshak Melzer; Fabrizia Lattanzio Journal: J Clin Med Date: 2020-01-21 Impact factor: 4.241