| Literature DB >> 22923015 |
Mridul Kanti Mandal1, Kentaro Yoshimura, Lee Chuin Chen, Zhan Yu, Tadao Nakazawa, Ryohei Katoh, Hideki Fujii, Sen Takeda, Hiroshi Nonami, Kenzo Hiraoka.
Abstract
We have examined several combinations of solvents with the aim of optimizing the ionization conditions for molecular diagnosis of malignant tumours by PESI-MS. Although the best conditions may depend on the actual species in the sample, the optimal conditions for renal cell carcinoma (RCC) were achieved by using alcohols. PESI-MS successfully delineated the differential expression of phospholipids (PCs) and triacylglycerols (TAGs) in noncancerous and RCC tissues by using these solvent systems. This study paves the way for the application of PESI-MS in medical samples.Entities:
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Year: 2012 PMID: 22923015 DOI: 10.1007/s13361-012-0462-3
Source DB: PubMed Journal: J Am Soc Mass Spectrom ISSN: 1044-0305 Impact factor: 3.109