AIM: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. METHODS: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S+L+) and control (S-L-, S+L-, S-L+) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S+L+ or S-L- groups. RESULTS: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. CONCLUSION:PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.
RCT Entities:
AIM: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. METHODS: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S+L+) and control (S-L-, S+L-, S-L+) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S+L+ or S-L- groups. RESULTS: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. CONCLUSION: PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.
Authors: Tina Rödig; Sarah Endres; Frank Konietschke; Ortrud Zimmermann; Hans Georg Sydow; Annette Wiegand Journal: Clin Oral Investig Date: 2016-09-03 Impact factor: 3.573