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Literature DB >> 22921080

2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases.

Pinhong Chen¹, Lori B Horton, Rose L Mikulski, Lisheng Deng, Sandeep Sundriyal, Timothy Palzkill, Yongcheng Song.

Abstract

Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors. Structure activity relationship (SAR) and molecular modeling studies were performed and implications for further inhibitor design are discussed.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2012 PMID： 22921080 PMCID： PMC3463135 DOI： 10.1016/j.bmcl.2012.08.012

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

22 in total

1. Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis.

Authors: Isabel C Materon; Anne Marie Queenan; Theresa M Koehler; Karen Bush; Timothy Palzkill
Journal: Antimicrob Agents Chemother Date: 2003-06 Impact factor: 5.191

Review 2. Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity.

Authors: Jed F Fisher; Samy O Meroueh; Shahriar Mobashery
Journal: Chem Rev Date: 2005-02 Impact factor: 60.622

Review 3. Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria.

Authors: Michael W Crowder; James Spencer; Alejandro J Vila
Journal: Acc Chem Res Date: 2006-10 Impact factor: 22.384

4. Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Authors: Lisheng Deng; Sandeep Sundriyal; Valentina Rubio; Zheng-zheng Shi; Yongcheng Song
Journal: J Med Chem Date: 2009-11-12 Impact factor: 7.446

5. Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase.

Authors: J H Toney; G G Hammond; P M Fitzgerald; N Sharma; J M Balkovec; G P Rouen; S H Olson; M L Hammond; M L Greenlee; Y D Gao
Journal: J Biol Chem Date: 2001-06-04 Impact factor: 5.157

Review 6. Metallo-beta-lactamase inhibitors: promise for the future?

Authors: Jeffrey H Toney; Joseph G Moloughney
Journal: Curr Opin Investig Drugs Date: 2004-08

7. Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.

Authors: N O Concha; C A Janson; P Rowling; S Pearson; C A Cheever; B P Clarke; C Lewis; M Galleni; J M Frère; D J Payne; J H Bateson; S S Abdel-Meguid
Journal: Biochemistry Date: 2000-04-18 Impact factor: 3.162

8. Analysis of the functional contributions of Asn233 in metallo-β-lactamase IMP-1.

Authors: Nicholas G Brown; Lori B Horton; Wanzhi Huang; Sompong Vongpunsawad; Timothy Palzkill
Journal: Antimicrob Agents Chemother Date: 2011-09-06 Impact factor: 5.191

Review 9. Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily.

Authors: Carine Bebrone
Journal: Biochem Pharmacol Date: 2007-06-02 Impact factor: 5.858

10. Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships.

Authors: Yan Lu; Chien-Ming Li; Zhao Wang; Charles R Ross; Jianjun Chen; James T Dalton; Wei Li; Duane D Miller
Journal: J Med Chem Date: 2009-03-26 Impact factor: 7.446

11 in total

Review 1. Fragment-based inhibitor discovery against β-lactamase.

Authors: Derek A Nichols; Adam R Renslo; Yu Chen
Journal: Future Med Chem Date: 2014-03 Impact factor: 3.808

2. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.

Authors: Orville A Pemberton; Priyadarshini Jaishankar; Afroza Akhtar; Jessie L Adams; Lindsey N Shaw; Adam R Renslo; Yu Chen
Journal: J Med Chem Date: 2019-09-13 Impact factor: 7.446

Review 3. Overcoming resistance to β-lactam antibiotics.

Authors: Roberta J Worthington; Christian Melander
Journal: J Org Chem Date: 2013-03-28 Impact factor: 4.354

Review 4. Diversity and Proliferation of Metallo-β-Lactamases: a Clarion Call for Clinically Effective Metallo-β-Lactamase Inhibitors.

Authors: Anou M Somboro; John Osei Sekyere; Daniel G Amoako; Sabiha Y Essack; Linda A Bester
Journal: Appl Environ Microbiol Date: 2018-08-31 Impact factor: 4.792

5. Spectroscopic and biochemical characterization of metallo-β-lactamase IMP-1 with dicarboxylic, sulfonyl, and thiol inhibitors.

Authors: Huan Zhang; Kundi Yang; Zishuo Cheng; Caitlyn Thomas; Abbie Steinbrunner; Cecily Pryor; Maya Vulcan; Claire Kemp; Diego Orea; Chathura Paththamperuma; Allie Y Chen; Seth M Cohen; Richard C Page; David L Tierney; Michael W Crowder
Journal: Bioorg Med Chem Date: 2021-05-01 Impact factor: 3.461

Review 6. Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism.

Authors: Antonella R Palacios; María-Agustina Rossi; Graciela S Mahler; Alejandro J Vila
Journal: Biomolecules Date: 2020-06-03

7. N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa.

Authors: Samir Yahiaoui; Katrin Voos; Jörg Haupenthal; Thomas A Wichelhaus; Denia Frank; Lilia Weizel; Marco Rotter; Steffen Brunst; Jan S Kramer; Ewgenij Proschak; Christian Ducho; Anna K H Hirsch
Journal: RSC Med Chem Date: 2021-07-29