PURPOSE: To examine the properties of N-butyl cyanoacrylate (NBCA) and iodized oil (lipiodol [Lip]) in vitro and in vivo for safe and effective embolization. MATERIALS AND METHODS: Viscosity, polymerization time, and diffusing capacity were evaluated according to the NBCA/Lip ratio in vitro. Additionally, the effect of the NBCA/Lip ratio on arterial embolization was evaluated in vivo; various ratios of NBCA/Lip were injected into the renal arteries of adult beagles, after which the embolization effect following transcatheter arterial embolization was quantitatively investigated histopathologically and using computed tomography (CT) volumetry. RESULTS: The viscosity of NBCA/Lip increased, polymerization time was prolonged, and diffusing capacity increased as the NBCA density decreased. As the NBCA density decreased, embolic material was recognized in smaller diameter arteries, and embolization of a larger vascular bed was accomplished. The NBCA/Lip mixture with a low density of NBCA was located more peripherally from the catheter tip, and embolization of more peripheral and smaller diameter arteries was achieved. CONCLUSIONS: The relationships of properties of NBCA/Lip in vitro and embolization effects in vivo of various ratios of NBCA/Lip were quantitatively examined and compared. The results of this study are useful for safe and effective embolization.
PURPOSE: To examine the properties of N-butyl cyanoacrylate (NBCA) and iodizedoil (lipiodol [Lip]) in vitro and in vivo for safe and effective embolization. MATERIALS AND METHODS: Viscosity, polymerization time, and diffusing capacity were evaluated according to the NBCA/Lip ratio in vitro. Additionally, the effect of the NBCA/Lip ratio on arterial embolization was evaluated in vivo; various ratios of NBCA/Lip were injected into the renal arteries of adult beagles, after which the embolization effect following transcatheter arterial embolization was quantitatively investigated histopathologically and using computed tomography (CT) volumetry. RESULTS: The viscosity of NBCA/Lip increased, polymerization time was prolonged, and diffusing capacity increased as the NBCA density decreased. As the NBCA density decreased, embolic material was recognized in smaller diameter arteries, and embolization of a larger vascular bed was accomplished. The NBCA/Lip mixture with a low density of NBCA was located more peripherally from the catheter tip, and embolization of more peripheral and smaller diameter arteries was achieved. CONCLUSIONS: The relationships of properties of NBCA/Lip in vitro and embolization effects in vivo of various ratios of NBCA/Lip were quantitatively examined and compared. The results of this study are useful for safe and effective embolization.
Authors: Osman Koç; Kadir Acar; Orhan Özbek; İbrahim Güler; Kadir Sarıtaş; Tuba Bera Erdem; Yalçın Solak; Hatice Toy; Ahmet Küçükapan; Seda Özbek; Abduzhappar Gaipov; İbrahim C Haznedaroğlu Journal: Diagn Interv Radiol Date: 2016 Jul-Aug Impact factor: 2.630
Authors: Daniel Kuetting; Patrick Kupczyk; Tatjana Dell; Julian A Luetkens; Carsten Meyer; Ulrike I Attenberger; Claus C Pieper Journal: Biomedicines Date: 2022-05-21
Authors: Rajanikant R Yadav; Deb K Boruah; Vishwaroop Bhattacharyya; Raghunandan Prasad; Sheo Kumar; V A Saraswat; V K Kapoor; Rajan Saxena Journal: J Clin Imaging Sci Date: 2016-12-20
Authors: Keun Young Park; Jin Woo Kim; Byung Moon Kim; Dong Joon Kim; Joonho Chung; Chang Ki Jang; Jun Hwee Kim Journal: Korean J Radiol Date: 2019-08 Impact factor: 3.500