| Literature DB >> 2292036 |
J K Wamsley1, W F Herblin, M E Alburges, M Hunt.
Abstract
Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177. Both receptor subtypes appear to exist in the brain, but the type 1 receptor predominates in the small regions of brain where AII binding is highly concentrated. DUP 753 may have a central action involved in its unique antihypertensive effect.Entities:
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Year: 1990 PMID： 2292036 DOI： 10.1016/0361-9230(90)90226-p
Source DB: PubMed Journal: Brain Res Bull ISSN： 0361-9230 Impact factor: 4.077