Literature DB >> 2291983

Function of granulocytes in B-chronic lymphatic leukaemia.

D Dekaris1, S Handl, A Sabioncello, S Rabatić.   

Abstract

To study the function of granulocytes in patients with B-cell chronic lymphatic leukaemia (B-CLL), granulocytes were separated from peripheral blood of 48 patients (mean age: 69 years) and 35 apparently healthy age-matched volunteers. Spontaneous mobility, ingestion, digestion and antibody dependent cellular cytotoxicity (ADCC) of granulocytes were assessed. Decreased spontaneous mobility was found in granulocytes from patients with B-CLL but between the two groups no detectable differences were encountered in the other parameters tested. No alterations of granulocytes functions were found to be correlated with clinical stages of B-CLL. If granulocytes functions were compared in treated (chlorambucil, steroids) and untreated patients, a significant decrease in digestion was found in treated patients.

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Mesh：

Year:  1990        PMID： 2291983     DOI： 10.1007/bf01738549

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  16 in total

1.  Clinical staging of chronic lymphocytic leukemia.

Authors:  K R Rai; A Sawitsky; E P Cronkite; A D Chanana; R N Levy; B S Pasternack
Journal:  Blood       Date:  1975-08       Impact factor: 22.113

2.  THE ROLE OF THE PHAGOCYTE IN HOST-PARASITE INTERACTIONS. I. THE PHAGOCYTIC CAPABILITIES OF LEUKOCYTES FROM LYMPHOPROLIFERATIVE DISORDERS.

Authors:  A J SBARRA; W SHIRLEY; R J SELVARAJ; E IOUCHI; E ROSENBAUM
Journal:  Cancer Res       Date:  1964-12       Impact factor: 12.701

3.  Age-dependent variations of intralysosomal enzyme release from human PMN leukocytes under various stimuli.

Authors:  T Fülöp; I Komáromi; G Fóris; I Wórum; A Leövey
Journal:  Immunobiology       Date:  1986-04       Impact factor: 3.144

4.  Age-related changes in functions of peripheral blood phagocytes.

Authors:  S Rabatić; A Sabioncello; D Dekaris; I Kardum
Journal:  Mech Ageing Dev       Date:  1988-11-30       Impact factor: 5.432

5.  Clinical disorders of leukocyte functions.

Authors:  H R Hill
Journal:  Contemp Top Immunobiol       Date:  1984

Review 6.  Chronic lymphocytic leukemia. Recent advances in biology and treatment.

Authors:  R P Gale; K A Foon
Journal:  Ann Intern Med       Date:  1985-07       Impact factor: 25.391

7.  Reduced phagocytosis promoting activity of saliva from patients with chronic lymphocytic leukemia.

Authors:  M Mittelman; P Fishman; M Djaldetti
Journal:  Biomed Pharmacother       Date:  1986       Impact factor: 6.529

8.  Human blood monocyte function in relation to age.

Authors:  H Nielsen; J Blom; S O Larsen
Journal:  Acta Pathol Microbiol Immunol Scand C       Date:  1984-02

9.  Age-dependent alterations of Fc gamma receptor-mediated effector functions of human polymorphonuclear leucocytes.

Authors:  T Fülöp; G Fóris; I Wórum; A Leövey
Journal:  Clin Exp Immunol       Date:  1985-08       Impact factor: 4.330

10.  Age differences in phagocytosis by polymorphonuclear leukocytes measured by flow cytometry.

Authors:  J E Nagel; K Han; P J Coon; W H Adler; B S Bender
Journal:  J Leukoc Biol       Date:  1986-04       Impact factor: 4.962
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