Literature DB >> 22918466

The impact of differential antiviral immunity in children and adults.

Andrew J Prendergast1, Paul Klenerman, Philip J R Goulder.   

Abstract

The course of immune maturation has evolved to favour survival at each stage of development in early life. Fetal and neonatal immune adaptations facilitate intrauterine survival and provide early postnatal protection against extracellular pathogens, but they leave infants susceptible to intracellular pathogens such as viruses that are acquired perinatally. This Review focuses on three such pathogens--HIV, hepatitis B virus and cytomegalovirus--and relates the differential impact of these infections in infants and adults to the antiviral immunity that is generated at different ages. A better understanding of age-specific antiviral immunity may inform the development of integrated prevention, treatment and vaccine strategies to minimize the global disease burden resulting from these infections.

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Year:  2012        PMID： 22918466     DOI： 10.1038/nri3277

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  180 in total

1.  Low HCMV DNA copies can establish infection and result in significant symptoms in extremely preterm infants: a prospective study.

Authors:  Hitomi Wakabayashi; Katsumi Mizuno; Chikara Kohda; Takaharu Negoro; Chiaki Maekawa; Satomi Sawato; Kazuo Tanaka; Yasuko Nakano; Junichirou Murayama; Motohiro Taki; Tokuo Miyazawa; Masahiko Murase; Madoka Aizawa; Yuuya Nakano; Motoichiro Sakurai; Kenichiro Takahashi; Kazuo Itabashi
Journal:  Am J Perinatol       Date:  2012-02-03       Impact factor: 1.862

2.  Cytomegalovirus infection during pregnancy with maternofetal transmission induces a proinflammatory cytokine bias in placenta and amniotic fluid.

Authors:  Gillian M Scott; Sharon S W Chow; Maria E Craig; Chi N I Pang; Beverley Hall; Marc R Wilkins; Cheryl A Jones; Andrew R Lloyd; William D Rawlinson
Journal:  J Infect Dis       Date:  2012-03-01       Impact factor: 5.226

3.  Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus.

Authors:  Scott G Hansen; Colin J Powers; Rebecca Richards; Abigail B Ventura; Julia C Ford; Don Siess; Michael K Axthelm; Jay A Nelson; Michael A Jarvis; Louis J Picker; Klaus Früh
Journal:  Science       Date:  2010-04-02       Impact factor: 47.728

4.  Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance.

Authors:  A Makrigiannakis; E Zoumakis; S Kalantaridou; C Coutifaris; A N Margioris; G Coukos; K C Rice; A Gravanis; G P Chrousos
Journal:  Nat Immunol       Date:  2001-11       Impact factor: 25.606

5.  Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.

Authors:  Jeff E Mold; Shivkumar Venkatasubrahmanyam; Trevor D Burt; Jakob Michaëlsson; Jose M Rivera; Sofiya A Galkina; Kenneth Weinberg; Cheryl A Stoddart; Joseph M McCune
Journal:  Science       Date:  2010-12-17       Impact factor: 47.728

6.  Restoring function in exhausted CD8 T cells during chronic viral infection.

Authors:  Daniel L Barber; E John Wherry; David Masopust; Baogong Zhu; James P Allison; Arlene H Sharpe; Gordon J Freeman; Rafi Ahmed
Journal:  Nature       Date:  2005-12-28       Impact factor: 49.962

7.  The significance of spontaneous hepatitis B e antigen seroconversion in childhood: with special emphasis on the clearance of hepatitis B e antigen before 3 years of age.

Authors:  M H Chang; H Y Hsu; H C Hsu; Y H Ni; J S Chen; D S Chen
Journal:  Hepatology       Date:  1995-11       Impact factor: 17.425

8.  Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children.

Authors:  Wenwei Tu; Sharon Chen; Margaret Sharp; Corry Dekker; Anne Marie Manganello; Eileen C Tongson; Holden T Maecker; Tyson H Holmes; Zhaoti Wang; George Kemble; Stuart Adler; Ann Arvin; David B Lewis
Journal:  J Immunol       Date:  2004-03-01       Impact factor: 5.422

9.  Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.

Authors:  Philippa C Matthews; Andrew Prendergast; Alasdair Leslie; Hayley Crawford; Rebecca Payne; Christine Rousseau; Morgane Rolland; Isobella Honeyborne; Jonathan Carlson; Carl Kadie; Christian Brander; Karen Bishop; Nonkululeko Mlotshwa; James I Mullins; Hoosen Coovadia; Thumbi Ndung'u; Bruce D Walker; David Heckerman; Philip J R Goulder
Journal:  J Virol       Date:  2008-07-02       Impact factor: 5.103

10.  Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection.

Authors:  A Ross Lopes; Paul Kellam; Abhishek Das; Claire Dunn; Antonia Kwan; Joanna Turner; Dimitra Peppa; Richard J Gilson; Adam Gehring; Antonio Bertoletti; Mala K Maini
Journal:  J Clin Invest       Date:  2008-05       Impact factor: 14.808
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  88 in total

1.  Nonalcoholic fatty liver disease is associated with lower hepatitis B viral load and antiviral response in pediatric population.

Authors:  Lu Wang; Yijin Wang; Shuhong Liu; Xiangwei Zhai; Guangde Zhou; Fengmin Lu; Jingmin Zhao
Journal:  J Gastroenterol       Date:  2019-05-27       Impact factor: 7.527

Review 2.  Gut microbiota modulate the immune effect against hepatitis B virus infection.

Authors:  D Xu; Y Huang; J Wang
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2015-08-14       Impact factor: 3.267

3.  Comparison of antibody response to hepatitis B vaccination in infants with positive or negative maternal hepatitis B e antigen (HBeAg) in cord blood: implication for the role of HBeAg as an immunotolerogen.

Authors:  Hongyu Huang; Mingzhe Ning; Jingli Liu; Jie Chen; Jing Feng; Yimin Dai; Yali Hu; Yi-Hua Zhou
Journal:  Hum Vaccin Immunother       Date:  2019-03-19       Impact factor: 3.452

Review 4.  Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health.

Authors:  Marcus Altfeld; Madeleine J Bunders
Journal:  Semin Immunopathol       Date:  2016-07-08       Impact factor: 9.623

5.  Pulmonary Dendritic Cell Subsets Shape the Respiratory Syncytial Virus-Specific CD8+ T Cell Immunodominance Hierarchy in Neonates.

Authors:  Allison M W Malloy; Tracy J Ruckwardt; Kaitlyn M Morabito; Annie W Lau-Kilby; Barney S Graham
Journal:  J Immunol       Date:  2016-11-28       Impact factor: 5.422

Review 6.  HIV-exposed uninfected children: a growing population with a vulnerable immune system?

Authors:  L Afran; M Garcia Knight; E Nduati; B C Urban; R S Heyderman; S L Rowland-Jones
Journal:  Clin Exp Immunol       Date:  2014-04       Impact factor: 4.330

7.  Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection.

Authors:  K Lind; E Svedin; R Utorova; V M Stone; M Flodström-Tullberg
Journal:  Clin Exp Immunol       Date:  2014-09       Impact factor: 4.330

Review 8.  Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species.

Authors:  Bridgette D Semple; Klas Blomgren; Kayleen Gimlin; Donna M Ferriero; Linda J Noble-Haeusslein
Journal:  Prog Neurobiol       Date:  2013-04-11       Impact factor: 11.685

9.  Development of serum antibodies during early infancy in rhesus macaques: implications for humoral immune responses to vaccination at birth.

Authors:  Ronald S Veazey; Chanjuan Shen; Huanbin Xu; David Liu; Xiaolei Wang
Journal:  Vaccine       Date:  2014-08-01       Impact factor: 3.641

Review 10.  Immunology of pediatric HIV infection.

Authors:  Nicole H Tobin; Grace M Aldrovandi
Journal:  Immunol Rev       Date:  2013-07       Impact factor: 12.988
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