AIMS: In patients with ST-segment elevation myocardial infarction (STEMI), timely reperfusion with primary percutaneous coronary intervention (PPCI) is the preferred treatment. However, it remains unclear whether the optimal strategy is complete revascularisation or culprit vessel PPCI only. METHODS AND RESULTS: From January 2002 to June 2009 all patients treated with PPCI were identified from the Western Denmark Heart Registry. We examined mortality according to timing of multivessel PCI: acute procedure, staged procedure during the index hospitalisation, or staged procedure performed within 60 days. The hazard ratio (HR) for death was estimated using a time-dependent Cox regression model, with time of PCI for the non-culprit lesion as the time-dependent variable. The study cohort consisted of 5,944 patients, of whom 4,770 (80%) had single-vessel disease and 1,174 (20%) had multivessel PCI within 60 days. Among 354 (30.2%) patients with acute multivessel PCI, 194 (16.5%) patients with multivessel PCI during the index hospitalisation, and 626 (53.3%) patients with multivessel PCI within 60 days after the index hospitalisation, the adjusted HRs for one-year mortality were 1.53 (95% confidence interval (CI): 1.07-2.18), 0.60 (95% CI: 0.28-1.26), and 0.28 (95% CI: 0.14-0.54), respectively, compared to patients with single vessel disease. CONCLUSIONS: Acute multivessel PCI in patients with STEMI was associated with increased mortality.
AIMS: In patients with ST-segment elevation myocardial infarction (STEMI), timely reperfusion with primary percutaneous coronary intervention (PPCI) is the preferred treatment. However, it remains unclear whether the optimal strategy is complete revascularisation or culprit vessel PPCI only. METHODS AND RESULTS: From January 2002 to June 2009 all patients treated with PPCI were identified from the Western Denmark Heart Registry. We examined mortality according to timing of multivessel PCI: acute procedure, staged procedure during the index hospitalisation, or staged procedure performed within 60 days. The hazard ratio (HR) for death was estimated using a time-dependent Cox regression model, with time of PCI for the non-culprit lesion as the time-dependent variable. The study cohort consisted of 5,944 patients, of whom 4,770 (80%) had single-vessel disease and 1,174 (20%) had multivessel PCI within 60 days. Among 354 (30.2%) patients with acute multivessel PCI, 194 (16.5%) patients with multivessel PCI during the index hospitalisation, and 626 (53.3%) patients with multivessel PCI within 60 days after the index hospitalisation, the adjusted HRs for one-year mortality were 1.53 (95% confidence interval (CI): 1.07-2.18), 0.60 (95% CI: 0.28-1.26), and 0.28 (95% CI: 0.14-0.54), respectively, compared to patients with single vessel disease. CONCLUSIONS: Acute multivessel PCI in patients with STEMI was associated with increased mortality.
Authors: Troels Thim; Gro Egholm; Kevin Kris Warnakula Olesen; Anne Kaltoft; Christian Juhl Terkelsen; Lars Romer Krusell; Steen Dalby Kristensen; Hans Erik Bøtker; Evald Høj Christiansen; Michael Maeng Journal: Open Heart Date: 2016-06-24
Authors: Inna Kim; Min Chul Kim; Hae Chang Jeong; Keun Ho Park; Doo Sun Sim; Young Joon Hong; Ju Han Kim; Myung Ho Jeong; Jeong Gwan Cho; Jong Chun Park; Ki-Bae Seung; Kiyuk Chang; Youngkeun Ahn Journal: Korean Circ J Date: 2016-12-12 Impact factor: 3.243
Authors: P A Vriesendorp; J M Wilschut; R Diletti; J Daemen; I Kardys; F Zijlstra; N M Van Mieghem; J Bennett; G Esposito; M Sabate; W K den Dekker Journal: Neth Heart J Date: 2022-05-10 Impact factor: 2.854
Authors: Min Chul Kim; Myung Ho Jeong; Sang Hyung Kim; Young Joon Hong; Ju Han Kim; Youngkeun Ahn Journal: Korean Circ J Date: 2014-05 Impact factor: 3.243