AIMS: Transcatheter aortic valve implantation (TAVI) has emerged as a treatment alternative to surgical aortic valve replacement in elderly high-risk patients with symptomatic severe aortic stenosis. In this patient population, rapid improvement or restoration of quality of life (QoL) is at least as important as improved clinical outcomes. The purpose of the present study was to assess changes in QoL in response to TAVI. METHODS AND RESULTS: Between August 2007 and August 2010, 62 patients (39% females, age 83 ± 5 years) underwent TAVI and were included in this QoL study. QoL was impaired at baseline and improved in all components of physical and mental health at nine months of follow-up: physical functioning (37.0 to 59.0, p<0.0001), physical role functioning (18.3 to 49.1, p<0.0001), general health (55.9 to 64.9, p=0.001), vitality (40.7 to 51.3, p<0.001), social functioning (67.4 to 76.8, p=0.049), emotional functioning (52.0 to 75.8, p<0.001) and mental health (66.6 to 75.8, p=0.05). The subscale bodily pain (60.7 to 70.4, p=0.058) showed a strong trend to improvement, but failed to reach statistical significance. Besides changes in health-related QoL, TAVI significantly improved symptoms (NYHA class 2.6 ± 0.8 to 1.4 ± 0.6, p<0.0001). CONCLUSIONS: TAVI leads to rapid and sustained restoration of all aspects of mental and physical health and effectively alleviates symptoms.
AIMS: Transcatheter aortic valve implantation (TAVI) has emerged as a treatment alternative to surgical aortic valve replacement in elderly high-risk patients with symptomatic severe aortic stenosis. In this patient population, rapid improvement or restoration of quality of life (QoL) is at least as important as improved clinical outcomes. The purpose of the present study was to assess changes in QoL in response to TAVI. METHODS AND RESULTS: Between August 2007 and August 2010, 62 patients (39% females, age 83 ± 5 years) underwent TAVI and were included in this QoL study. QoL was impaired at baseline and improved in all components of physical and mental health at nine months of follow-up: physical functioning (37.0 to 59.0, p<0.0001), physical role functioning (18.3 to 49.1, p<0.0001), general health (55.9 to 64.9, p=0.001), vitality (40.7 to 51.3, p<0.001), social functioning (67.4 to 76.8, p=0.049), emotional functioning (52.0 to 75.8, p<0.001) and mental health (66.6 to 75.8, p=0.05). The subscale bodily pain (60.7 to 70.4, p=0.058) showed a strong trend to improvement, but failed to reach statistical significance. Besides changes in health-related QoL, TAVI significantly improved symptoms (NYHA class 2.6 ± 0.8 to 1.4 ± 0.6, p<0.0001). CONCLUSIONS: TAVI leads to rapid and sustained restoration of all aspects of mental and physical health and effectively alleviates symptoms.
Authors: Nicolas A Geis; Emmanuel Chorianopoulos; Klaus Kallenbach; Florian André; Sven T Pleger; Matthias Karck; Hugo A Katus; Raffi Bekeredjian Journal: Clin Res Cardiol Date: 2014-04-21 Impact factor: 5.460
Authors: Moritz Seiffert; Jan-Malte Sinning; Alexander Meyer; Sandra Wilde; Lenard Conradi; Mariuca Vasa-Nicotera; Alexander Ghanem; Jörg Kempfert; Christoph Hammerstingl; Francisco M Ojeda; Won-Keun Kim; Dietmar H Koschyk; Johannes Schirmer; Stephan Baldus; Eberhard Grube; Helge Möllmann; Hermann Reichenspurner; Georg Nickenig; Stefan Blankenberg; Patrick Diemert; Hendrik Treede; Thomas Walther; Nikos Werner; Renate B Schnabel Journal: Clin Res Cardiol Date: 2014-03-19 Impact factor: 5.460
Authors: Katarzyna Olszewska-Turek; Tomasz Tokarek; Artur Dziewierz; Anna Rajtar-Zembaty; Bartosz Partyński; Danuta Sorysz; Barbara Bętkowska-Korpała Journal: Postepy Kardiol Interwencyjnej Date: 2020-04-03 Impact factor: 1.426
Authors: Caroline A Kim; Suraj P Rasania; Jonathan Afilalo; Jeffrey J Popma; Lewis A Lipsitz; Dae Hyun Kim Journal: Ann Intern Med Date: 2014-02-18 Impact factor: 25.391
Authors: Katarzyna Olszewska; Tomasz Tokarek; Barbara Bętkowska-Korpała; Artur Dziewierz; Paweł Kleczyński; Danuta Sorysz; Dariusz Dudek Journal: Postepy Kardiol Interwencyjnej Date: 2017-09-25 Impact factor: 1.426