| Literature DB >> 22917271 |
Matthias Groh1, Daniel Meidlinger, Gerhard Bringmann, Andreas Speicher.
Abstract
The Heck protocol was applied for the first time to the atroposelective synthesis of macrocyclic natural products. As ring closure to bis(bibenzyls) of the isoplagiochin type leads to a configurationally stable biaryl axis in the molecule, cyclization could be conducted atroposelectively in the presence of a chiral BINAP ligand.Entities:
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Year: 2012 PMID： 22917271 DOI： 10.1021/ol302132s
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005