Literature DB >> 22916954

Hepatoprotective iridoid glycosides from the roots of Rehmannia glutinosa.

Yan-Fei Liu1, Dong Liang, Huan Luo, Zhi-You Hao, Yan Wang, Chun-Lei Zhang, Qing-Jian Zhang, Ruo-Yun Chen, De-Quan Yu.   

Abstract

Eleven new iridoid glycosides, rehmaglutosides A-K (1-11), together with 20 known analogues were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 3, 7, and 9-11 (10 μM) exhibited moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.

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Year:  2012        PMID: 22916954     DOI: 10.1021/np300509z

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  6 in total

1.  Metabolite accumulation and metabolic network in developing roots of Rehmannia glutinosa reveals its root developmental mechanism and quality.

Authors:  Yanqing Zhou; Ke Yang; Dandan Zhang; Hongying Duan; Yongkang Liu; Mengmeng Guo
Journal:  Sci Rep       Date:  2018-09-20       Impact factor: 4.379

2.  Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α.

Authors:  Ling Wang; Xue-Min Qiu; Yu-Yan Gui; Ying-Ping Xu; Hans-Jürgen Gober; Da-Jin Li
Journal:  Drug Des Devel Ther       Date:  2015-07-21       Impact factor: 4.162

3.  Simultaneous Determination of Catalpol, Aucubin, and Geniposidic Acid in Different Developmental Stages of Rehmannia glutinosa Leaves by High Performance Liquid Chromatography.

Authors:  Yanjie Wang; Dengqun Liao; Minjian Qin; Xian'en Li
Journal:  J Anal Methods Chem       Date:  2016-06-26       Impact factor: 2.193

4.  Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.

Authors:  Meng Li; Mengnan Zeng; Zhi-Guang Zhang; Beibei Zhang; Jingke Zhang; Xiaoke Zheng; Weisheng Feng
Journal:  Evid Based Complement Alternat Med       Date:  2018-09-04       Impact factor: 2.629

5.  Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.

Authors:  Hui-Xian Xu; Shu-Xia Lin; Yuewen Gong; Zi-Xuan Huo; Cheng-Yun Zhao; Hong-Mei Zhu; Sheng-Yan Xi
Journal:  Front Pharmacol       Date:  2020-03-24       Impact factor: 5.810

6.  Diversity of secoiridoid glycosides in leaves of UK and Danish ash provide new insight for ash dieback management.

Authors:  John D Sidda; Lijiang Song; Jack L Parker; David J Studholme; Christine Sambles; Murray Grant
Journal:  Sci Rep       Date:  2020-11-11       Impact factor: 4.379

  6 in total

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