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Literature DB >> 22914774

Chemoenzymatic preparation of germacrene analogues.

Oscar Cascón¹, Sabrina Touchet, David J Miller, Veronica Gonzalez, Juan A Faraldos, Rudolf K Allemann.

Abstract

A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.

Entities: Chemical

Mesh：

Substances：

Year: 2012 PMID： 22914774 DOI： 10.1039/c2cc35542f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

11 in total

1. Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues.

Authors: Anwei Hou; Jeroen S Dickschat
Journal: Chemistry Date: 2021-09-29 Impact factor: 5.020

2. Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases.

Authors: Juan A Faraldos; Veronica Gonzalez; Amang Li; Fanglei Yu; Mustafa Köksal; David W Christianson; Rudolf K Allemann
Journal: J Am Chem Soc Date: 2012-12-11 Impact factor: 15.419

Review 3. Chemoenzymatic approaches to plant natural product inspired compounds.

Authors: Rebecca Roddan; Eve M Carter; Benjamin Thair; Helen C Hailes
Journal: Nat Prod Rep Date: 2022-07-20 Impact factor: 15.111

4. An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde.

Authors: Melodi Demiray; Xiaoping Tang; Thomas Wirth; Juan A Faraldos; Rudolf K Allemann
Journal: Angew Chem Int Ed Engl Date: 2017-03-13 Impact factor: 15.336

5. Concise synthesis of artemisinin from a farnesyl diphosphate analogue.

Authors: Xiaoping Tang; Melodi Demiray; Thomas Wirth; Rudolf K Allemann
Journal: Bioorg Med Chem Date: 2017-04-04 Impact factor: 3.641

6. Sesquiterpene Synthase-Catalysed Formation of a New Medium-Sized Cyclic Terpenoid Ether from Farnesyl Diphosphate Analogues.

Authors: Florence Huynh; Daniel J Grundy; Robert L Jenkins; David J Miller; Rudolf K Allemann
Journal: Chembiochem Date: 2018-07-16 Impact factor: 3.164

Chemoenzymatic preparation of germacrene analogues.

1. Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues.

2. Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases.

Review 3. Chemoenzymatic approaches to plant natural product inspired compounds.

4. An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde.

5. Concise synthesis of artemisinin from a farnesyl diphosphate analogue.

6. Sesquiterpene Synthase-Catalysed Formation of a New Medium-Sized Cyclic Terpenoid Ether from Farnesyl Diphosphate Analogues.

7. Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids.

8. High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase.

9. Optimising Terpene Synthesis with Flow Biocatalysis.

10. Enzymatic Synthesis of Methylated Terpene Analogues Using the Plasticity of Bacterial Terpene Synthases.