Literature DB >> 22913573

Peristomal lichen sclerosus: the role of occlusion and urine exposure?

F Al-Niaimi1, C Lyon.   

Abstract

BACKGROUND: Lichen sclerosus (LS) is a chronic inflammatory skin disorder that typically affects the anogenital area. It presents with ivory-white atrophic patches or plaques with associated telangiectasia and occasional purpura. It has rarely been described as affecting abdominal stomas.
OBJECTIVES: To investigate possible aetiological factors responsible for the development of this condition.
METHODS: All patients with peristomal LS were identified at a specialist stoma dermatology clinic and studied using a standardized pro forma.
RESULTS: We identified 12 patients with peristomal LS. The mean age was 72·3 years (range 47-85 years). With the exception of one patient, all our other patients had urostomies. Treatment was effective in the majority of cases.
CONCLUSIONS: Peristomal LS, in our experience, is most commonly found around urostomies, and we speculate that in addition to the possible role of local trauma and occlusion, certain - as yet unidentified - constituents in the urine possibly play a role in its aetiology. It tends to respond well to corticosteroids and has not been associated with malignant transformation.
© 2012 The Authors. BJD © 2012 British Association of Dermatologists.

Entities:  

Mesh:

Year:  2013        PMID: 22913573     DOI: 10.1111/bjd.12014

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN: 0007-0963            Impact factor:   9.302


  6 in total

Review 1.  The Immunogenetics of Morphea and Lichen Sclerosus.

Authors:  Pooya Khan Mohammad Beigi
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

2.  Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta-analysis.

Authors:  L Kirby; S Gran; I Kreuser-Genis; C Owen; R Simpson
Journal:  Skin Health Dis       Date:  2021-02-12

Review 3.  Male genital lichen sclerosus.

Authors:  Christopher Barry Bunker; Tang Ngee Shim
Journal:  Indian J Dermatol       Date:  2015 Mar-Apr       Impact factor: 1.494

4.  Lichen sclerosus: the role of oxidative stress in the pathogenesis of the disease and its possible transformation into carcinoma.

Authors:  Gianni Paulis; Enzo Berardesca
Journal:  Res Rep Urol       Date:  2019-08-20

Review 5.  [What's new in clinical dermatology?].

Authors:  M Janier
Journal:  Ann Dermatol Venereol       Date:  2013-11       Impact factor: 0.777

6.  The role of occlusion and micro-incontinence in the pathogenesis of penile lichen sclerosus: an observational study of pro-inflammatory cytokines' gene expression.

Authors:  M Czajkowski; P Wierzbicki; A Kotulak-Chrząszcz; K Czajkowska; M Bolcewicz; J Kłącz; K Kreft; A Lewandowska; B Nedoszytko; M Sokołowska-Wojdyło; Z Kmieć; L Kalinowski; R J Nowicki; M Matuszewski
Journal:  Int Urol Nephrol       Date:  2022-02-01       Impact factor: 2.370

  6 in total

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