OBJECTIVES: The primary objective of this study was to investigate the feasibility of using niosomes as a delivery vehicle for the dermal administration in vitro of black tea extract (BTE) as a sunscreen. METHODS: Multi-lamellar niosomes were obtained by means of a previously reported method of lipid hydration films. In vitro penetration experiments through nude mouse skin were carried out to evaluate the potential of niosomes as a dermal formulation. The nude mouse skin membrane allowed the effects of penetration with a niosome formulation to be evaluated. Penetration rates of caffeine- and gallic acid-loaded niosomes in a steady state were higher than dispersion in aqueous solutions. RESULTS: For skin permeation, higher transdermal absorption rates were seen with solutions of caffeine and gallic acid. CONCLUSIONS: In the near future, BTE as a sunscreen agent will be dermally delivered by niosomes.
OBJECTIVES: The primary objective of this study was to investigate the feasibility of using niosomes as a delivery vehicle for the dermal administration in vitro of black tea extract (BTE) as a sunscreen. METHODS: Multi-lamellar niosomes were obtained by means of a previously reported method of lipid hydration films. In vitro penetration experiments through nude mouse skin were carried out to evaluate the potential of niosomes as a dermal formulation. The nude mouse skin membrane allowed the effects of penetration with a niosome formulation to be evaluated. Penetration rates of caffeine- and gallic acid-loaded niosomes in a steady state were higher than dispersion in aqueous solutions. RESULTS: For skin permeation, higher transdermal absorption rates were seen with solutions of caffeine and gallic acid. CONCLUSIONS: In the near future, BTE as a sunscreen agent will be dermally delivered by niosomes.
Authors: Tawona N Chinembiri; Minja Gerber; Lissinda H du Plessis; Jan L du Preez; Josias H Hamman; Jeanetta du Plessis Journal: Pharmacogn Mag Date: 2017-10-11 Impact factor: 1.085
Authors: Zarith Asyikin Abdul Aziz; Hasmida Mohd-Nasir; Akil Ahmad; Siti Hamidah Mohd Setapar; Wong Lee Peng; Sing Chuong Chuo; Asma Khatoon; Khalid Umar; Asim Ali Yaqoob; Mohamad Nasir Mohamad Ibrahim Journal: Front Chem Date: 2019-11-13 Impact factor: 5.221