Literature DB >> 22911247

Fluorocyclohexanes: synthesis and structure of all-syn-1,2,4,5-tetrafluorocyclohexane.

Alastair J Durie1, Alexandra M Z Slawin, Tomas Lebl, Peer Kirsch, David O'Hagan.   

Abstract

The all-syn isomer of 1,2,4,5-tetrafluorocyclohexane is prepared and characterised by NMR and X-ray crystallography. It emerges to be a particularly polar cyclohexane analogue with differentially polarised faces.

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Year:  2012        PMID： 22911247     DOI： 10.1039/c2cc34679f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane.

Authors:  Neil S Keddie; Alexandra M Z Slawin; Tomas Lebl; Douglas Philp; David O'Hagan
Journal:  Nat Chem       Date:  2015-04-13       Impact factor: 24.427

2.  Organofluorine chemistry: A Janus cyclohexane ring.

Authors:  Nico Santschi; Ryan Gilmour
Journal:  Nat Chem       Date:  2015-04-13       Impact factor: 24.427

3.  Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane.

Authors:  Mohammed Salah Ayoup; David B Cordes; Alexandra M Z Slawin; David O'Hagan
Journal:  Beilstein J Org Chem       Date:  2015-12-21       Impact factor: 2.883

4.  Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif.

Authors:  Tetiana Bykova; Nawaf Al-Maharik; Alexandra M Z Slawin; David O'Hagan
Journal:  Beilstein J Org Chem       Date:  2017-04-19       Impact factor: 2.883

5.  Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring.

Authors:  Mathew J Jones; Ricardo Callejo; Alexandra M Z Slawin; Michael Bühl; David O'Hagan
Journal:  Beilstein J Org Chem       Date:  2016-12-22       Impact factor: 2.883

6.  Metabolism and hydrophilicity of the polarised 'Janus face' all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery.

Authors:  Andrea Rodil; Stefano Bosisio; Mohammed Salah Ayoup; Laura Quinn; David B Cordes; Alexandra M Z Slawin; Cormac D Murphy; Julien Michel; David O'Hagan
Journal:  Chem Sci       Date:  2018-02-19       Impact factor: 9.825

7.  Understanding the Conformational Behavior of Fluorinated Piperidines: The Origin of the Axial-F Preference.

Authors:  Zackaria Nairoukh; Felix Strieth-Kalthoff; Klaus Bergander; Frank Glorius
Journal:  Chemistry       Date:  2020-05-12       Impact factor: 5.236

Review 8.  Selective Arene Hydrogenation for Direct Access to Saturated Carbo- and Heterocycles.

Authors:  Mario P Wiesenfeldt; Zackaria Nairoukh; Toryn Dalton; Frank Glorius
Journal:  Angew Chem Int Ed Engl       Date:  2019-04-29       Impact factor: 15.336
  8 in total

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