Literature DB >> 22911019

A Weinreb amide approach to the synthesis of trifluoromethylketones.

DiAndra M Rudzinski1, Christopher B Kelly, Nicholas E Leadbeater.   

Abstract

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF(3)) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.

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Year:  2012        PMID： 22911019     DOI： 10.1039/c2cc35037h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

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Authors:  O Andreea Argintaru; DaWeon Ryu; Ioana Aron; Gary A Molander
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2.  Synthesis of Leu-Enkephalin Peptidomimetics Containing Trifluoromethylalkenes as Amide Isopolar Mimics.

Authors:  Venkateswararao Eeda; Manikandan Selvaraju; Ryan A Altman
Journal:  J Fluor Chem       Date:  2018-12-11       Impact factor: 2.050

3.  Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold.

Authors:  Sören Baumeister; Dirk Schepmann; Bernhard Wünsch
Journal:  Medchemcomm       Date:  2019-01-10       Impact factor: 3.597

4.  β-Amino functionalization of cinnamic Weinreb amides in ionic liquid.

Authors:  Yi-Ning Wang; Guo-Xiang Sun; Gang Qi
Journal:  Beilstein J Org Chem       Date:  2016-11-11       Impact factor: 2.883

5.  Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

Authors:  Colin R Wilson; Richard K Gessner; Atica Moosa; Ronnett Seldon; Digby F Warner; Valerie Mizrahi; Candice Soares de Melo; Sandile B Simelane; Aloysius Nchinda; Efrem Abay; Dale Taylor; Mathew Njoroge; Christel Brunschwig; Nina Lawrence; Helena I M Boshoff; Clifton E Barry; Frederick A Sirgel; Paul van Helden; C John Harris; Richard Gordon; Sonja Ghidelli-Disse; Hannah Pflaumer; Markus Boesche; Gerard Drewes; Olalla Sanz; Gracia Santos; Maria José Rebollo-Lopez; Beatriz Urones; Carolyn Selenski; Maria Jose Lafuente-Monasterio; Matthew Axtman; Joël Lelièvre; Lluis Ballell; Rudolf Mueller; Leslie J Street; Sandeep R Ghorpade; Kelly Chibale
Journal:  J Med Chem       Date:  2017-12-07       Impact factor: 7.446

6.  Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.

Authors:  Isabel V L Wilkinson; Kelly J Perkins; Hannah Dugdale; Lee Moir; Aini Vuorinen; Maria Chatzopoulou; Sarah E Squire; Sebastian Monecke; Alexander Lomow; Marcus Geese; Philip D Charles; Peter Burch; Jonathan M Tinsley; Graham M Wynne; Stephen G Davies; Francis X Wilson; Fraydoon Rastinejad; Shabaz Mohammed; Kay E Davies; Angela J Russell
Journal:  Angew Chem Int Ed Engl       Date:  2020-01-03       Impact factor: 15.336
  6 in total

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