V Bagnardi1, M Rota2, E Botteri3, I Tramacere4, F Islami5, V Fedirko6, L Scotti7, M Jenab6, F Turati8, E Pasquali9, C Pelucchi4, R Bellocco10, E Negri4, G Corrao7, J Rehm11, P Boffetta12, C La Vecchia13. 1. Department of Statistics, University of Milan-Bicocca, Milan; Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan. Electronic address: vincenzo.bagnardi@unimib.it. 2. Department of Clinical Medicine and Prevention, Centre of Biostatistics for Clinical Epidemiology, University of Milan-Bicocca, Monza. 3. Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan; Department of Occupational Health, University of Milan, Milan. 4. Department of Epidemiology, Mario Negri Institute for Pharmacological Research 'Mario Negri', Milan, Italy. 5. The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA; Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran. 6. Nutritional Epidemiology Group, International Agency for Research on Cancer, Lyon, France. 7. Department of Statistics, University of Milan-Bicocca, Milan. 8. Department of Occupational Health, University of Milan, Milan; Department of Epidemiology, Mario Negri Institute for Pharmacological Research 'Mario Negri', Milan, Italy. 9. Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan. 10. Department of Statistics, University of Milan-Bicocca, Milan; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. 11. Social and Epidemiological Research Department, Centre for Addiction and Mental Health, Toronto; Dalla Lana School of Public Health Department, University of Toronto, Toronto, Canada. 12. The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA; International Prevention Research Institute, Lyon, France. 13. Department of Occupational Health, University of Milan, Milan; Department of Epidemiology, Mario Negri Institute for Pharmacological Research 'Mario Negri', Milan, Italy; International Prevention Research Institute, Lyon, France.
Abstract
BACKGROUND: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). PATIENTS AND METHODS: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. RESULTS: We included 222 articles comprising ∼92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ∼5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. CONCLUSIONS: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.
BACKGROUND: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). PATIENTS AND METHODS: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. RESULTS: We included 222 articles comprising ∼92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ∼5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. CONCLUSIONS: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.
Authors: Michelle L Baglia; Linda S Cook; C Mei-Tzu; Charles Wiggins; Deirdre Hill; Peggy Porter; Christopher I Li Journal: Int J Cancer Date: 2018-07-26 Impact factor: 7.396