Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Down syndrome DSCR1 causes spine pathology via the Fragile X-related protein FMRP.

Literature DB >> 22909818

Down syndrome DSCR1 causes spine pathology via the Fragile X-related protein FMRP.

Francesco Roselli¹.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2012 PMID： 22909818 PMCID： PMC3442279 DOI： 10.1038/emboj.2012.239

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

× No keyword cloud information.

10 in total

1. Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.

Authors: Katherine R Martin; Alicia Corlett; Daphne Dubach; Tomris Mustafa; Harold A Coleman; Helena C Parkington; Tobias D Merson; James A Bourne; Sílvia Porta; Maria L Arbonés; David I Finkelstein; Melanie A Pritchard
Journal: Hum Mol Genet Date: 2012-04-17 Impact factor: 6.150

2. Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling.

Authors: Ravi S Muddashetty; Vijayalaxmi C Nalavadi; Christina Gross; Xiaodi Yao; Lei Xing; Oskar Laur; Stephen T Warren; Gary J Bassell
Journal: Mol Cell Date: 2011-06-10 Impact factor: 17.970

3. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome.

Authors: Emily K Osterweil; Dilja D Krueger; Kimberly Reinhold; Mark F Bear
Journal: J Neurosci Date: 2010-11-17 Impact factor: 6.167

4. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.

Authors: Dan Ehninger; Sangyeul Han; Carrie Shilyansky; Yu Zhou; Weidong Li; David J Kwiatkowski; Vijaya Ramesh; Alcino J Silva
Journal: Nat Med Date: 2008-06-22 Impact factor: 53.440

5. DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis.

Authors: Wei Wang; John Z Zhu; Karen T Chang; Kyung-Tai Min
Journal: EMBO J Date: 2012-08-03 Impact factor: 11.598

Review 6. Molecular genetic analysis of Down syndrome.

Authors: David Patterson
Journal: Hum Genet Date: 2009-06-13 Impact factor: 4.132

7. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.

Authors: Aubin Michalon; Michael Sidorov; Theresa M Ballard; Laurence Ozmen; Will Spooren; Joseph G Wettstein; Georg Jaeschke; Mark F Bear; Lothar Lindemann
Journal: Neuron Date: 2012-04-12 Impact factor: 17.173

8. Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.

Authors: Jennifer A Ronesi; Katie A Collins; Seth A Hays; Nien-Pei Tsai; Weirui Guo; Shari G Birnbaum; Jia-Hua Hu; Paul F Worley; Jay R Gibson; Kimberly M Huber
Journal: Nat Neurosci Date: 2012-01-22 Impact factor: 24.884

9. Mutations causing syndromic autism define an axis of synaptic pathophysiology.

Authors: Benjamin D Auerbach; Emily K Osterweil; Mark F Bear
Journal: Nature Date: 2011-11-23 Impact factor: 49.962

10. Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis.

Authors: Pirta Hotulainen; Olaya Llano; Sergei Smirnov; Kimmo Tanhuanpää; Jan Faix; Claudio Rivera; Pekka Lappalainen
Journal: J Cell Biol Date: 2009-04-20 Impact factor: 10.539