BACKGROUND/ OBJECTIVES: The alarming increase in obesity worldwide is of concern, owing to the associations of obesity with metabolic syndrome (MetS), which has been associated with a proinflammatory state characterized by elevated plasma concentrations of several markers of inflammation. The aim of this study was to assess levels of inflammatory markers and their association with MetS among adolescents. SUBJECTS/ METHODS: A random sample of adolescents (n=362, 143 boys and 219 girls, 12-17 years) was interviewed, anthropometrically measured and provided a fasting blood sample. Circulating levels of adiponectin, leptin, tumour necrosis factor-alpha, plasminogen activator inhibitor 1 (PAI-1), interleukin-6 and high-sensitivity C-reactive protein were measured. The association between inflammatory markers and sex, age, body mass index (BMI) status, MetS, physical activity and blood pressure was also calculated. RESULTS: Adiponectin levels are inversely associated and leptin levels are directly associated with MetS and BMI, but directly with gender (females show higher levels than boys), and PAI-1 levels are directly associated with MetS, among adolescents. CONCLUSIONS: Leptin, adiponectin and PAI-1 may be used as biomarkers to predict MetS among adolescents.
BACKGROUND/ OBJECTIVES: The alarming increase in obesity worldwide is of concern, owing to the associations of obesity with metabolic syndrome (MetS), which has been associated with a proinflammatory state characterized by elevated plasma concentrations of several markers of inflammation. The aim of this study was to assess levels of inflammatory markers and their association with MetS among adolescents. SUBJECTS/ METHODS: A random sample of adolescents (n=362, 143 boys and 219 girls, 12-17 years) was interviewed, anthropometrically measured and provided a fasting blood sample. Circulating levels of adiponectin, leptin, tumour necrosis factor-alpha, plasminogen activator inhibitor 1 (PAI-1), interleukin-6 and high-sensitivity C-reactive protein were measured. The association between inflammatory markers and sex, age, body mass index (BMI) status, MetS, physical activity and blood pressure was also calculated. RESULTS:Adiponectin levels are inversely associated and leptin levels are directly associated with MetS and BMI, but directly with gender (females show higher levels than boys), and PAI-1 levels are directly associated with MetS, among adolescents. CONCLUSIONS:Leptin, adiponectin and PAI-1 may be used as biomarkers to predict MetS among adolescents.
Authors: Priscila L Sanches; Marco T de Mello; Natália Elias; Francisco A H Fonseca; Raquel M S Campos; June Carnier; Aline de Piano; Deborah C L Masquio; Patrícia L Silva; Lila M Oyama; Flavia C Corgosinho; Cláudia M O Nascimento; Lian Tock; Carolina Ackel D'Elia; Sergio Tufik; Ana R Dâmaso Journal: Inflammation Date: 2014-02 Impact factor: 4.092
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Authors: Ivana Zagotta; Elitsa Y Dimova; Jan-Bernd Funcke; Martin Wabitsch; Thomas Kietzmann; Pamela Fischer-Posovszky Journal: Oxid Med Cell Longev Date: 2013-06-02 Impact factor: 6.543
Authors: Julia D Rempel; Juliet Packiasamy; Heather J Dean; Jonathon McGavock; Alyssa Janke; Mark Collister; Brandy Wicklow; Elizabeth A C Sellers Journal: Int J Circumpolar Health Date: 2013-08-05 Impact factor: 1.228
Authors: Andreas Leiherer; Kathrin Stoemmer; Axel Muendlein; Christoph H Saely; Elena Kinz; Eva M Brandtner; Peter Fraunberger; Heinz Drexel Journal: Nutrients Date: 2016-05-12 Impact factor: 5.717