OBJECTIVE: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipokine potentially linking obesity, insulin resistance and type 2 diabetes. Here, we searched for genetic determinants that could explain the variability in serum vaspin concentrations. RESEARCH DESIGN AND METHODS: First, we conducted a genome-wide association study (GWAS) for serum vaspin in the Sorbs cohort (N=826). Subsequently, 26 single-nucleotide polymorphisms (SNPs) covering genetic variation in the vaspin locus were genotyped in the Sorbs. In addition, we measured serum vaspin concentrations in 1806 samples from Augsburg/the Cooperative Health Research in the Region of Augsburg (KORA) for replication of the association signals. Finally, we conducted association analyses of vaspin SNPs with metabolic traits in the Sorbs (N=1013), KORA (N=1813) and a further cohort from Germany (Leipzig: N=1857). RESULTS: Six SNPs mapping between serpinA1 and serpinA4, including the vaspin locus, on chromosome 14 reached P-values < or = 10(-8) in the GWAS in the Sorbs. The fine mapping of variants within the vaspin locus in the Sorbs and subsequent replication in the KORA sample revealed several SNPs significantly associated with serum vaspin concentrations reaching P-values of up to 10(-35). However, no significant association with type 2 diabetes or related traits was found in either cohort after the Bonferroni correction for multiple comparisons. CONCLUSION: Our data show that the variability in serum vaspin concentrations might be explained by its genetic variants.
OBJECTIVE:Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipokine potentially linking obesity, insulin resistance and type 2 diabetes. Here, we searched for genetic determinants that could explain the variability in serum vaspin concentrations. RESEARCH DESIGN AND METHODS: First, we conducted a genome-wide association study (GWAS) for serum vaspin in the Sorbs cohort (N=826). Subsequently, 26 single-nucleotide polymorphisms (SNPs) covering genetic variation in the vaspin locus were genotyped in the Sorbs. In addition, we measured serum vaspin concentrations in 1806 samples from Augsburg/the Cooperative Health Research in the Region of Augsburg (KORA) for replication of the association signals. Finally, we conducted association analyses of vaspin SNPs with metabolic traits in the Sorbs (N=1013), KORA (N=1813) and a further cohort from Germany (Leipzig: N=1857). RESULTS: Six SNPs mapping between serpinA1 and serpinA4, including the vaspin locus, on chromosome 14 reached P-values < or = 10(-8) in the GWAS in the Sorbs. The fine mapping of variants within the vaspin locus in the Sorbs and subsequent replication in the KORA sample revealed several SNPs significantly associated with serum vaspin concentrations reaching P-values of up to 10(-35). However, no significant association with type 2 diabetes or related traits was found in either cohort after the Bonferroni correction for multiple comparisons. CONCLUSION: Our data show that the variability in serum vaspin concentrations might be explained by its genetic variants.
Authors: Jana Breitfeld; John T Heiker; Yvonne Böttcher; Dorit Schleinitz; Anke Tönjes; Kerstin Weidle; Kerstin Krause; E Bartholomeus Kuettner; Markus Scholz; Wieland Kiess; Norbert Sträter; Annette G Beck-Sickinger; Michael Stumvoll; Antje Körner; Matthias Blüher; Peter Kovacs Journal: J Mol Med (Berl) Date: 2013-06-12 Impact factor: 4.599
Authors: Anke Tönjes; Markus Scholz; Jana Breitfeld; Carola Marzi; Harald Grallert; Arnd Gross; Claes Ladenvall; Dorit Schleinitz; Kerstin Krause; Holger Kirsten; Esa Laurila; Jennifer Kriebel; Barbara Thorand; Wolfgang Rathmann; Leif Groop; Inga Prokopenko; Bo Isomaa; Frank Beutner; Jürgen Kratzsch; Joachim Thiery; Mathias Fasshauer; Nora Klöting; Christian Gieger; Matthias Blüher; Michael Stumvoll; Peter Kovacs Journal: PLoS Genet Date: 2014-12-18 Impact factor: 5.917
Authors: Hassan M Salama; Ashraf Galal; Ayat A Motawie; Ashraf F Kamel; Doaa M Ibrahim; Azza A Aly; Emman A Hassan Journal: Open Access Maced J Med Sci Date: 2015-11-26
Authors: Jana Breitfeld; Anke Tönjes; Marie-Therese Gast; Dorit Schleinitz; Matthias Blüher; Michael Stumvoll; Peter Kovacs; Yvonne Böttcher Journal: PLoS One Date: 2013-01-14 Impact factor: 3.240
Authors: Claudia Grellmann; Jane Neumann; Sebastian Bitzer; Peter Kovacs; Anke Tönjes; Lars T Westlye; Ole A Andreassen; Michael Stumvoll; Arno Villringer; Annette Horstmann Journal: Front Genet Date: 2016-06-07 Impact factor: 4.599