INTRODUCTION AND METHODS: This study compared changes in myokine and myogenic genes following resistance exercise (3 sets of 12 repetitions of maximal unilateral knee extension) in 20 elderly men (67.8 ± 1.0 years) and 15 elderly women (67.2 ± 1.5 years). RESULTS: Monocyte chemotactic protein (MCP)-1, macrophage inhibitory protein (MIP)-1β, interleukin (IL)-6 and MyoD mRNA increased significantly (P < 0.05), whereas myogenin and myostatin mRNA decreased significantly after exercise in both groups. Macrophage-1 (Mac-1) and MCP-3 mRNA did not change significantly after exercise in either group. MIP-1β, Mac-1 and myostatin mRNA were significantly higher before and after exercise in men compared with women. In contrast, MCP-3 and myogenin mRNA were significantly higher before and after exercise in the women compared with the men. CONCLUSIONS: In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury.
INTRODUCTION AND METHODS: This study compared changes in myokine and myogenic genes following resistance exercise (3 sets of 12 repetitions of maximal unilateral knee extension) in 20 elderly men (67.8 ± 1.0 years) and 15 elderly women (67.2 ± 1.5 years). RESULTS:Monocyte chemotactic protein (MCP)-1, macrophage inhibitory protein (MIP)-1β, interleukin (IL)-6 and MyoD mRNA increased significantly (P < 0.05), whereas myogenin and myostatin mRNA decreased significantly after exercise in both groups. Macrophage-1 (Mac-1) and MCP-3 mRNA did not change significantly after exercise in either group. MIP-1β, Mac-1 and myostatin mRNA were significantly higher before and after exercise in men compared with women. In contrast, MCP-3 and myogenin mRNA were significantly higher before and after exercise in the women compared with the men. CONCLUSIONS: In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury.
Authors: Jeffrey D Covington; Charmaine S Tam; Sudip Bajpeyi; Jose E Galgani; Robert C Noland; Steven R Smith; Leanne M Redman; Eric Ravussin Journal: Med Sci Sports Exerc Date: 2016-03 Impact factor: 5.411
Authors: Aliza B Rubenstein; J Matthew Hinkley; Venugopalan D Nair; German Nudelman; Robert A Standley; Fanchao Yi; GongXin Yu; Todd A Trappe; Marcas M Bamman; Scott W Trappe; Lauren M Sparks; Bret H Goodpaster; Rick B Vega; Stuart C Sealfon; Elena Zaslavsky; Paul M Coen Journal: Am J Physiol Endocrinol Metab Date: 2022-01-24 Impact factor: 4.310
Authors: Xiao Švec; Hana Štorkánová; Maja Špiritović; Kryštof Slabý; Sabína Oreská; Aneta Pekáčová; Barbora Heřmánková; Kristýna Bubová; Petr Česák; Haya Khouri; Gulalai Amjad; Heřman Mann; Martin Komarc; Karel Pavelka; Ladislav Šenolt; Josef Zámečník; Jiří Vencovský; Michal Tomčík Journal: Int J Mol Sci Date: 2022-09-28 Impact factor: 6.208