BACKGROUND: Sorbents have been shown to adsorb iodinated radiocontrast media. OBJECTIVE: In this study we describe a simple method to compare various sorbents in terms of capacity to adsorb radiocontrast media. METHODS: Iodixanol solution was injected into columns filled with three types of sorbent at filtration velocities of increasing magnitude. Two variables of interest - contrast removal rate and matched iodine retention (MIR) - were calculated to measure the adsorption efficiency and the mass of contrast iodine adsorbed versus sorbent used, respectively. RESULTS: The highest contrast removal and MIR for Porapak Q, CST 401 and Amberlite XAD4 were 41, 38 and 16% (p = 0.22 and 0.0005 for comparisons between Porapak Q-CST 401 and CST 401-Amberlite XAD4) and 0.060, 0.055 and 0.024, respectively (p = 0.18 and 0.0008). Extrapolation to a clinical scenario may suggest that removal of 8 ml iodixanol could be achieved by masses of sorbents of 43, 47 and 107 g, respectively. CONCLUSION: In this study we set a benchmark for comparing the radiocontrast-adsorbing efficiency of polymer sorbents during first-pass experiments, using a readily available methodology.
BACKGROUND: Sorbents have been shown to adsorb iodinated radiocontrast media. OBJECTIVE: In this study we describe a simple method to compare various sorbents in terms of capacity to adsorb radiocontrast media. METHODS:Iodixanol solution was injected into columns filled with three types of sorbent at filtration velocities of increasing magnitude. Two variables of interest - contrast removal rate and matched iodine retention (MIR) - were calculated to measure the adsorption efficiency and the mass of contrast iodine adsorbed versus sorbent used, respectively. RESULTS: The highest contrast removal and MIR for Porapak Q, CST 401 and Amberlite XAD4 were 41, 38 and 16% (p = 0.22 and 0.0005 for comparisons between Porapak Q-CST 401 and CST 401-Amberlite XAD4) and 0.060, 0.055 and 0.024, respectively (p = 0.18 and 0.0008). Extrapolation to a clinical scenario may suggest that removal of 8 ml iodixanol could be achieved by masses of sorbents of 43, 47 and 107 g, respectively. CONCLUSION: In this study we set a benchmark for comparing the radiocontrast-adsorbing efficiency of polymer sorbents during first-pass experiments, using a readily available methodology.
Authors: Thomas Köhler; Elke Schwier; Janina Praxenthaler; Carmen Kirchner; Dietrich Henzler; Claas Eickmeyer Journal: Int J Mol Sci Date: 2021-11-26 Impact factor: 5.923
Authors: George O Angheloiu; Gabriel B Gugiu; Cristian Ruse; Rishikesh Pandey; Ramachandra R Dasari; Carl Whatling Journal: JACC Basic Transl Sci Date: 2017-04-24