Literature DB >> 22906307

Successful early neonatal repair of cleft lip within first 8 days of life.

Borsky Jiri1, Veleminska Jana, Jurovčík Michal, Kozak Jiri, Hechtova Dana, Tvrdek Miroslav, Cerny Milos, Kabelka Zdenek, Fajstavr Jaroslav, Janota Jan, Zach Jiri, Peterkova Renata, Peterka Miroslav.   

Abstract

OBJECTIVE: In the children born with a cleft lip, surgery is the first step in correcting the inborn anomaly. In comparison with usually made 3-month surgery, benefits of the surgery in neonates have been reported: a very good wound healing, feeding facilitation, and good socialization of a child from neonatal age. The aims of the present study were to perform cheiloplasty in early newborns affected by the total cleft lip and palate (CLP) by the technique modified to search for optimum aesthetic result, and to assess the surgery outcome from qualitative and quantitative aspects.
METHODS: The operations were performed by the same surgeon in 97 neonates 1-8 days old during 2005-2008. The original technique by Tennison was modified and used. Aesthetic outcome of the surgery was evaluated according to scar visibility, and the shape and symmetry of the lip and nose. The effect of cheiloplasty on the formation of the upper jaw segments was evaluated in a sample of unilateral CLP patients using the 3D-finite element scaling analysis (FESA). We compared 3D models of dental plaster casts made prior to lip surgery (in neonates under 8 days of age) and prior to palate surgery (at 12 months of age).
RESULTS: Only the children in excellent health state and without an associated inborn defect were allowed to pass the operation. There were no per-operative complications (except the correction of tracheal tube position in several cases). The parents appreciated bringing home a neonate with no visible cleft. This aspect not only facilitated baby feeding, but had important positive psycho-social impact on the whole family. The wound healing and aesthetic effect of the cheiloplasty were very good. The scar was barely visible and lip and nose were symmetric in majority of children. After lip closure, the growth and approximation of jaw segments was observed. This aspect was also associated with incisors development in the anterior portion of the segment including premaxilla.
CONCLUSIONS: Our results show, that early neonatal lip surgery of CLP is promising technique with very good aesthetic results and important positive psychological impact on the child and its family.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Year:  2012        PMID: 22906307     DOI: 10.1016/j.ijporl.2012.07.031

Source DB:  PubMed          Journal:  Int J Pediatr Otorhinolaryngol        ISSN: 0165-5876            Impact factor:   1.675


  4 in total

1.  Design of composite scaffolds and three-dimensional shape analysis for tissue-engineered ear.

Authors:  Thomas M Cervantes; Erik K Bassett; Alan Tseng; Anya Kimura; Nick Roscioli; Mark A Randolph; Joseph P Vacanti; Theresa A Hadlock; Rajiv Gupta; Irina Pomerantseva; Cathryn A Sundback
Journal:  J R Soc Interface       Date:  2013-07-31       Impact factor: 4.118

Review 2.  Cleft lip - a comprehensive review.

Authors:  Mahdi A Shkoukani; Michael Chen; Angela Vong
Journal:  Front Pediatr       Date:  2013-12-27       Impact factor: 3.418

3.  Functional differences between neonatal and adult fibroblasts and keratinocytes: Donor age affects epithelial-mesenchymal crosstalk in vitro.

Authors:  Rosana Mateu; Veronika Živicová; Eliška Drobná Krejčí; Miloš Grim; Hynek Strnad; Čestmír Vlček; Michal Kolář; Lukáš Lacina; Peter Gál; Jiří Borský; Karel Smetana; Barbora Dvořánková
Journal:  Int J Mol Med       Date:  2016-08-11       Impact factor: 4.101

4.  Analysis of dermal fibroblasts isolated from neonatal and child cleft lip and adult skin: Developmental implications on reconstructive surgery.

Authors:  Veronika Živicová; Lukáš Lacina; Rosana Mateu; Karel Smetana; Radana Kavková; Eliška Drobná Krejčí; Miloš Grim; Alena Kvasilová; Jiří Borský; Hynek Strnad; Miluše Hradilová; Jana Šáchová; Michal Kolář; Barbora Dvořánková
Journal:  Int J Mol Med       Date:  2017-09-07       Impact factor: 4.101

  4 in total

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