OBJECTIVES: This study evaluated the expression profile of the mesothelin (MSLN) gene and its prognostic significance in breast cancer. METHODS: To evaluate the diagnostic and prognostic significance of mesothelin, immunohistochemistry was used to assess the level of mesothelin protein in surgically resected, formalin-fixed, paraffin-embedded invasive breast carcinoma specimens. Associations between mesothelin and other biomarkers, including oestrogen receptor (OR), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2/neu), were also evaluated. RESULTS: A total of 182 breast carcinoma specimens were included. Mesothelin protein was present in the membrane of malignant cells. There was correlation between the presence of mesothelin in tumour cells and tumour infiltration of the lymph node. There was no correlation between the presence of mesothelin and HER2/neu protein, OR and PR in tumour cells. Mesothelin levels were significantly associated with decreased overall survival. CONCLUSIONS: Lymph node status, tumour size, HER2/neu and mesothelin protein levels in breast cancer cells were independent prognostic factors. Mesothelin could be useful as a prognostic marker of overall survival in invasive breast cancer.
OBJECTIVES: This study evaluated the expression profile of the mesothelin (MSLN) gene and its prognostic significance in breast cancer. METHODS: To evaluate the diagnostic and prognostic significance of mesothelin, immunohistochemistry was used to assess the level of mesothelin protein in surgically resected, formalin-fixed, paraffin-embedded invasive breast carcinoma specimens. Associations between mesothelin and other biomarkers, including oestrogen receptor (OR), progesterone receptor (PR) and humanepidermal growth factor receptor 2 (HER2/neu), were also evaluated. RESULTS: A total of 182 breast carcinoma specimens were included. Mesothelin protein was present in the membrane of malignant cells. There was correlation between the presence of mesothelin in tumour cells and tumour infiltration of the lymph node. There was no correlation between the presence of mesothelin and HER2/neu protein, OR and PR in tumour cells. Mesothelin levels were significantly associated with decreased overall survival. CONCLUSIONS: Lymph node status, tumour size, HER2/neu and mesothelin protein levels in breast cancer cells were independent prognostic factors. Mesothelin could be useful as a prognostic marker of overall survival in invasive breast cancer.
Authors: Napa Parinyanitikul; George R Blumenschein; Yun Wu; Xiudong Lei; Mariana Chavez-Macgregor; Melody Smart; Ana Maria Gonzalez-Angulo Journal: Clin Breast Cancer Date: 2013-06-27 Impact factor: 3.225
Authors: Yun R Li; Rena R Xian; Amy Ziober; Jose Conejo-Garcia; Alfredo Perales-Puchalt; Carl H June; Paul J Zhang; Julia Tchou Journal: Breast Cancer Res Treat Date: 2014-09-06 Impact factor: 4.872
Authors: Keagan P Collins; Sandra Witta; Jonathan W Coy; Yi Pang; Daniel L Gustafson Journal: J Pharmacol Exp Ther Date: 2020-11-10 Impact factor: 4.030