Literature DB >> 22903671

Modulation of dendritic cells and regulatory T cells by naturally occurring antibodies.

Jaap Kwekkeboom1.   

Abstract

Most studies on the effects of naturally occurring autoantibodies (NAbs) on immune cells have been performed in the context of research on the immunomodulatory effects of intravenous immunoglobulin (IVIG). Among others, IVIG inhibits the differentiation, maturation and functions of dendritic cells (DC), thereby suppressing T-cell activation. In addition, IVIG stimulates expansion and suppressive function of regulatory T cells (Treg) carrying the antigens CD4, CD25 and Foxp3. Current data on the immunomodulatory effects of IVIG on DC and Treg are summarized, and possible molecular interactions between NAbs and DC or Treg that mediate these effects are discussed.

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Year:  2012        PMID： 22903671     DOI： 10.1007/978-1-4614-3461-0_10

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  9 in total

1.  Anti-MAG autoantibodies are increased in Parkinson's disease but not in atypical parkinsonism.

Authors:  Ewa Papuć; Konrad Rejdak
Journal:  J Neural Transm (Vienna)       Date:  2016-10-20       Impact factor: 3.575

Review 2.  Intravenous immunoglobulins in liver transplant patients: Perspectives of clinical immune modulation.

Authors:  Arno Kornberg
Journal:  World J Hepatol       Date:  2015-06-18

3.  Patients treated with high-dose intravenous immunoglobulin show selective activation of regulatory T cells.

Authors:  A S W Tjon; T Tha-In; H J Metselaar; R van Gent; L J W van der Laan; Z M A Groothuismink; P A W te Boekhorst; P M van Hagen; J Kwekkeboom
Journal:  Clin Exp Immunol       Date:  2013-08       Impact factor: 4.330

4.  Modeling pre-existing immunity to adenovirus in rodents: immunological requirements for successful development of a recombinant adenovirus serotype 5-based ebola vaccine.

Authors:  Jin Huk Choi; Stephen C Schafer; Lihong Zhang; Terry Juelich; Alexander N Freiberg; Maria A Croyle
Journal:  Mol Pharm       Date:  2013-08-19       Impact factor: 4.939

Review 5.  Differences in Anti-Inflammatory Actions of Intravenous Immunoglobulin between Mice and Men: More than Meets the Eye.

Authors:  Angela S W Tjon; Rogier van Gent; Teunis B Geijtenbeek; Jaap Kwekkeboom
Journal:  Front Immunol       Date:  2015-04-28       Impact factor: 7.561

6.  An fc gamma receptor-mediated upregulation of the production of interleukin 10 by intravenous immunoglobulin in bone-marrow-derived mouse dendritic cells stimulated with lipopolysaccharide in vitro.

Authors:  Akihiro Fujii; Yuko Kase; Chiaki Suzuki; Akihito Kamizono; Teruaki Imada
Journal:  J Signal Transduct       Date:  2013-06-18

7.  IVIg and LPS Co-stimulation Induces IL-10 Production by Human Monocytes, Which Is Compromised by an FcγRIIA Disease-Associated Gene Variant.

Authors:  Lisa K Kozicky; Susan C Menzies; Zheng Yu Zhao; Tariq Vira; Kiera Harnden; Kwestan Safari; Kate L Del Bel; Stuart E Turvey; Laura M Sly
Journal:  Front Immunol       Date:  2018-11-20       Impact factor: 7.561

8.  Comparable autoantibody serum levels against amyloid- and inflammation-associated proteins in Parkinson's disease patients and controls.

Authors:  Walter Maetzler; Anja Apel; Markus Langkamp; Christian Deuschle; Sarah Selina Dilger; Johannes Georg Stirnkorb; Claudia Schulte; Erwin Schleicher; Thomas Gasser; Daniela Berg
Journal:  PLoS One       Date:  2014-02-21       Impact factor: 3.240

Review 9.  Immune modulation of i.v. immunoglobulin in women with reproductive failure.

Authors:  Ae R Han; Sung K Lee
Journal:  Reprod Med Biol       Date:  2018-01-24
  9 in total

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