| Literature DB >> 22903203 |
Talia Nir1, Neda Jahanshad, Clifford R Jack, Michael W Weiner, Arthur W Toga, Paul M Thompson.
Abstract
Alzheimer's Disease (AD) has long been considered a cortical degenerative disease, but impaired brain connectivity, due to white matter injury, may exacerbate cognitive problems. Predicting brain changes is critically important for early treatment. In a longitudinal diffusion tensor imaging study, we investigated white matter fiber integrity in 19 patients (mean age: 74.7 +/- 8.4 yrs at baseline) displaying early signs of mild cognitive impairment (eMCI). We first examined whether baseline average fractional anisotropy (FA) measures in the corpus callosum (CC) predicted changes in white matter integrity over the following 6 months. We then examined whether "small world" architecture measures - calculated from baseline connectivity maps - predicted white matter changes over the next 6 months. While average CC FA measures at baseline were not associated with future changes in FA, network measures were a sensitive biomarker for predicting white matter changes during this critical time before AD strikes.Entities:
Year: 2012 PMID： 22903203 PMCID： PMC3420972 DOI： 10.1109/ISBI.2012.6235831
Source DB: PubMed Journal: Proc IEEE Int Symp Biomed Imaging ISSN： 1945-7928