| Literature DB >> 22902653 |
Liqi He1, Steven P Seitz, George L Trainor, David Tortolani, Wayne Vaccaro, Michael Poss, Christine M Tarby, John S Tokarski, Becky Penhallow, Chen-Yi Hung, Ricardo Attar, Tai-An Lin.
Abstract
A series of aminothiazoles that are potent inhibitors of LIM kinases 1 and 2 is described. Appropriate choice of substituents led to molecules with good selectivity for either enzyme. An advanced member of the series was shown to effectively interfere with the phosphorylation of the LIM kinases substrate cofilin. Consistent with the important role of the LIM kinases in regulating cytoskeletal structure, treated cells displayed dramatically reduced F-actin content. Published by Elsevier Ltd.Entities:
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Year: 2012 PMID： 22902653 DOI： 10.1016/j.bmcl.2012.07.002
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823