| Literature DB >> 22901800 |
Veronica A Codelia1, Kenneth D Irvine.
Abstract
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.Entities:
Year: 2012 PMID: 22901800 DOI: 10.1016/j.cell.2012.07.020
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582