OBJECTIVE: The present study evaluated the efficacy of bone regeneration between synthetic octacalcium phosphate (OCP) granules combined with porcine atelocollagen (OCP/Col) and β-tricalcium phosphate (β-TCP). STUDY DESIGN: A disk of OCP/Col (20 mm diameter, 2.5 mm thick) or commercially available sintered porous β-TCP was implanted into a critical-sized calvarial defect (20 mm diameter) of adult male canines (n = 10). The newly formed bone in the defect was analyzed radiographically, crystallographically, histologically, and histomorphometrically at 6 months after implantation. RESULTS: Histomorphometry showed that there was significantly more newly formed bone in OCP/Col-treated defects than for β-TCP (P < .05). X-Ray diffraction patterns of implanted OCP/Col were similar to those of original bone and different from those of implanted β-TCP. CONCLUSIONS: These results suggest that OCP/Col implantation in canine critical-sized defect enhanced bone regeneration more than β-TCP, which is the most commonly used synthetic bone substitutes.
OBJECTIVE: The present study evaluated the efficacy of bone regeneration between synthetic octacalcium phosphate (OCP) granules combined with porcine atelocollagen (OCP/Col) and β-tricalcium phosphate (β-TCP). STUDY DESIGN: A disk of OCP/Col (20 mm diameter, 2.5 mm thick) or commercially available sintered porous β-TCP was implanted into a critical-sized calvarial defect (20 mm diameter) of adult male canines (n = 10). The newly formed bone in the defect was analyzed radiographically, crystallographically, histologically, and histomorphometrically at 6 months after implantation. RESULTS: Histomorphometry showed that there was significantly more newly formed bone in OCP/Col-treated defects than for β-TCP (P < .05). X-Ray diffraction patterns of implanted OCP/Col were similar to those of original bone and different from those of implanted β-TCP. CONCLUSIONS: These results suggest that OCP/Col implantation in canine critical-sized defect enhanced bone regeneration more than β-TCP, which is the most commonly used synthetic bone substitutes.
Authors: Hanna Pihlman; Pauli Keränen; Kaarlo Paakinaho; Jere Linden; Markus Hannula; Iida-Kaisa Manninen; Jari Hyttinen; Mikko Manninen; Outi Laitinen-Vapaavuori Journal: J Mater Sci Mater Med Date: 2018-10-08 Impact factor: 3.896