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Literature DB >> 22901441

Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia.

Marco Ferrari¹, Emilio Bolla, Paola Bortolaso, Camilla Callegari, Nicola Poloni, Sergio Lecchini, Simone Vender, Franca Marino, Marco Cosentino.

Abstract

We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2(⁎)1C and (⁎)1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019).

Entities: Chemical Disease Gene Species

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Year: 2012 PMID： 22901441 DOI： 10.1016/j.psychres.2012.07.002

Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222

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Cited

8 in total

1. Oral Antipsychotic Versus Long-Acting Injections Antipsychotic in Schizophrenia Spectrum Disorder: a Mirror Analysis in a Real-World Clinical Setting.

Authors: Nicola Poloni; Marta Ielmini; Ivano Caselli; Giulia Lucca; Alessandra Gasparini; Alessandra Gasparini; Giorgia Lorenzoli; Camilla Callegari
Journal: Psychopharmacol Bull Date: 2019-06-20

8. Pharmacogenetic Tests in Reducing Accesses to Emergency Services and Days of Hospitalization in Bipolar Disorder: A 2-Year Mirror Analysis.

Authors: Camilla Callegari; Celeste Isella; Ivano Caselli; Nicola Poloni; Marta Ielmini
Journal: J Pers Med Date: 2019-04-30

8 in total

Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia.

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8. Pharmacogenetic Tests in Reducing Accesses to Emergency Services and Days of Hospitalization in Bipolar Disorder: A 2-Year Mirror Analysis.