BACKGROUND: Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA. METHODS: Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times. RESULTS: The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT. CONCLUSION: This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.
BACKGROUND:Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA. METHODS: Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times. RESULTS: The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT. CONCLUSION: This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.
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Authors: Antonio Luigi Pastore; Giovanni Palleschi; Giorgia Manfredonia; Piero Maceroni; Domenico Alvaro; Domenico De Santis; Simone Ferretti; Natale Porta; Claudio Di Cristofano; Carlo Della Rocca; Andrea Fuschi; Yazan Al Salhi; Cristina Maggioni; Davide Moschese; Vincenzo Petrozza; Antonio Carbone Journal: BMC Gastroenterol Date: 2013-10-14 Impact factor: 3.067