| Literature DB >> 22900985 |
Yun-Long Guo1, Jian-Fei Bai, Lin Peng, Liang-Liang Wang, Li-Na Jia, Xi-Ya Luo, Fang Tian, Xiao-Ying Xu, Li-Xin Wang.
Abstract
The direct asymmetric vinylogous Mannich reaction of 3,4-dihalofuran-2(5H)-one with aldimine catalyzed by quinine was first reported, and γ-butenolides have been obtained in excellent yield (up to 98%) and enantioselectivities (up to 95% ee). The synthetic applications of this protocol are demonstrated in the preparations of γ-substituted amino butyrolactones and vicinal amino alcohols.Entities:
Year: 2012 PMID： 22900985 DOI： 10.1021/jo301115t
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354