| Literature DB >> 22900374 |
Neslihan Bukan1, Banu Sancak, Ozlem Yavuz, Cemile Koca, Funda Tutkun, A Tanju Ozçelikay, Nilgün Altan.
Abstract
In this study, alterations in the liver antioxidant enzymes status and lipid peroxidation in short-term (8-weeks) and long-term (24-weeks) diabetic rats were examined. Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) levels were significantly increased, but superoxide dismutase (SOD) activity was significantly reduced in 8-weeks diabetic rats, compared to control. Catalase (CAT) activity, however, was found unchanged. In 24-weeks diabetic rats, while GSH-Px activity was unchanged, but SOD and CAT activities and MDA levels were significantly increased, compared to control. These results suggest that diabetes-induced alterations in tissue antioxidant system may reflect a generalized increase in tissue oxidative stress. It can be concluded that lipid peroxidation and antioxidant enzyme levels are elevated in diabetic condition. Hence, diabetes mellitus, if left untreated, may increase degenerative processes due to accumulation of oxidative free radicals.Entities:
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Year: 2003 PMID： 22900374
Source DB: PubMed Journal: Indian J Biochem Biophys ISSN： 0301-1208 Impact factor: 1.918