Potent antibacterial activity of oligo-3-aminopyridine against Staphylococcus aureus and Enterococcus faecalis.

Oligo-3-aminopyridine (OAP) was tested for its antibacterial activity against two gram positive (Staphylococcus aureus and Enterococcus faecalis) and two gram negative (Escherchia coli and Pseudomonas aeruginosa) bacterial strains. Antibacterial efficacy was measured by disk diffusion assay. Inhibition zones demonstrated that 50 microg OAP showed strong antibacterial activity against the gram-positive strains; the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were found to be 25 microg/ml and 50 microg/ml, respectively. The results indicate that OAP is a potent antibacterial agent against S. aureus and E. faecalis.