Literature DB >> 228968

Corticosteroidogenesis by isolated human adrenal cells: effect of serotonin and serotonin antagonists.

K Rácz, I Wolf, R Kiss, G Lada, S Vida, E Gláz.   

Abstract

The direct effect of serotonin and antiserotonin agents on adrenal steroid biosynthesis was studied in isolated adrenal cells derived from patients with Cushing's syndrome. The results indicate that serotonin increases corticosterone production, while the serotonin antagonists cyproheptadine and methysergide depress adrenal steroid - particularly cortisol and aldosterone - biosynthesis.

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Year:  1979        PMID： 228968     DOI： 10.1007/bf01962830

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  Use of corticosteroid antibodies for the study of corticosteroid biosynthesis in vitro.

Authors:  P Vecsei; R Onyechi; J Hornung; R Dietz; G Mast; H Hobler
Journal:  J Steroid Biochem       Date:  1975 Mar-Apr       Impact factor: 4.292

2.  Serotonin regulation of ACTH secretion.

Authors:  D T Krieger
Journal:  Ann N Y Acad Sci       Date:  1977-10-28       Impact factor: 5.691

3.  Studies on isolated rat adrenal cells. I. Continuous flow and batch incubation.

Authors:  H E Falke; H J Degenhart; G J Abeln; H K Visser; R J Croughs
Journal:  Acta Endocrinol (Copenh)       Date:  1975-01

4.  Steroidogenesis in isolated rat adrenal glomerulosa cells: response to physiological concentrations of angiotensin II and effects of potassium, serotonin and [Sar1,Ala8]-angiotensin II.

Authors:  R F Bing; D Schulster
Journal:  J Endocrinol       Date:  1977-08       Impact factor: 4.286

5.  A technic for the preparation of isolated rat adrenal cells.

Authors:  R L Swallow; G Sayers
Journal:  Proc Soc Exp Biol Med       Date:  1969-05

6.  Aldosterone diagnosis in hypertension: comparative evaluation of radioimmunoassays for urinary aldosterone and 18-OH-corticosterone.

Authors:  T M Connolly; P Vecsei; D Haack; K H Kohl; S Abdelhamid; A Ammenti
Journal:  Klin Wochenschr       Date:  1978
  6 in total
  2 in total

Review 1.  Role of neurotransmitters and neuropeptides in the regulation of the adrenal cortex.

Authors:  C Delarue; V Contesse; S Lenglet; F Sicard; V Perraudin; H Lefebvre; M Kodjo; F Leboulenger; L Yon; N Gallo-Payet; H Vaudry
Journal:  Rev Endocr Metab Disord       Date:  2001-08       Impact factor: 6.514

2.  The effect of carcinoid levels of serotonin and substance P on hemodynamics.

Authors:  M J Zinner; C J Yeo; B M Jaffe
Journal:  Ann Surg       Date:  1984-02       Impact factor: 12.969
  2 in total

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