Literature DB >> 228966

Specific inhibition of a calcium dependent activation of brain cyclic AMP phosphodiesterase activity by vinblastine.

K Watanabe, E F Williams, J S Law, W L West.   

Abstract

Vinblastine selectively inhibits the activation of brain cyclic AMP phosphodiesterase activity by Ca++-protein activator (50% inhibition by 2 x 10(-5) M). This inhibitory effect was reversed by excessive amounts of the activator, whereas large quantities of Ca++ caused only a slight suppression of the vinblastine effect. This result of vinblastine suggests a new site of its action and also suggests the possible role of protein activator, phosphodiesterase proteins or cyclic nucleotides in the previously known effects of vinblastine in vivo and in vitro.

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Year:  1979        PMID： 228966     DOI： 10.1007/bf01962801

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  23 in total

1.  Characteristics of the cyclic nucleotide phosphodiesterases of normal and leukemic lymphocytes.

Authors:  W N Hait; B Weiss
Journal:  Biochim Biophys Acta       Date:  1977-03-29

2.  Interaction of chlorpromazine with brain microtubule subunit protein.

Authors:  J R Cann; N D Hinman
Journal:  Mol Pharmacol       Date:  1975-05       Impact factor: 4.436

3.  Control of microtubule assembly-disassembly by calcium-dependent regulator protein.

Authors:  J M Marcum; J R Dedman; B R Brinkley; A R Means
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

4.  Tubulin aggregation and disaggregation: mediation by two distinct vinblastine-binding sites.

Authors:  B Bhattacharyya; J Wolff
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

5.  Effects of zinc chloride on the hydrolysis of cyclic GMP and cyclic AMP by the activator-dependent cyclic nucleotide phosphodiesterase from bovine heart.

Authors:  T E Donnelly
Journal:  Biochim Biophys Acta       Date:  1978-01-12

6.  Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells.

Authors:  M J Welsh; J R Dedman; B R Brinkley; A R Means
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

7.  Mechanism of stimulation of Ca2+ plus Mg2+ -dependent phospodiesterase from rat cerebral cortex by the modulator protein and Ca2+.

Authors:  Y Teshima; S Kakiuchi
Journal:  Biochem Biophys Res Commun       Date:  1974-01-23       Impact factor: 3.575

8.  Purification and properties of the protein activator of bovine heart cyclic adenosine 3',5'-monophosphate phosphodiesterase.

Authors:  T S Teo; T H Wang; J H Wang
Journal:  J Biol Chem       Date:  1973-01-25       Impact factor: 5.157

9.  Purification and characterization of cyclic 3',5'-nucleotide phosphodiesterase from bovine brain.

Authors:  W Y Cheung; Y M Lin
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

10.  Cyclic 3',5'-nucleotide phosphodiesterase. Demonstration of an activator.

Authors:  W Y Cheung
Journal:  Biochem Biophys Res Commun       Date:  1970-02-06       Impact factor: 3.575
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  2 in total

1.  Comparison of the calmodulin antagonists compound 48/80 and calmidazolium.

Authors:  K Gietzen
Journal:  Biochem J       Date:  1983-12-15       Impact factor: 3.857

2.  A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors.

Authors:  K Gietzen; I Sadorf; H Bader
Journal:  Biochem J       Date:  1982-12-01       Impact factor: 3.857
  2 in total

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