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Literature DB >> 22895837

Imaging mitochondrial redox potential and its possible link to tumor metastatic potential.

Abstract

Cellular redox states can regulate cell metabolism, growth, differentiation, motility, apoptosis, signaling pathways, and gene expressions etc. A growing body of literature suggest the importance of redox status for cancer progression. While most studies on redox state were done on cells and tissue lysates, it is important to understand the role of redox state in a tissue in vivo/ex vivo and image its heterogeneity. Redox scanning is a clinical-translatable method for imaging tissue mitochondrial redox potential with a submillimeter resolution. Redox scanning data in mouse models of human cancers demonstrate a correlation between mitochondrial redox state and tumor metastatic potential. I will discuss the significance of this correlation and possible directions for future research.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2012 PMID： 22895837 PMCID： PMC3508148 DOI： 10.1007/s10863-012-9469-5

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

109 in total

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Authors: Richard L Veech
Journal: Biochem Mol Biol Educ Date: 2006-05 Impact factor: 1.160

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Authors: Colette T Dooley; Timothy M Dore; George T Hanson; W Coyt Jackson; S James Remington; Roger Y Tsien
Journal: J Biol Chem Date: 2004-02-25 Impact factor: 5.157

3. In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia.

Authors: Melissa C Skala; Kristin M Riching; Annette Gendron-Fitzpatrick; Jens Eickhoff; Kevin W Eliceiri; John G White; Nirmala Ramanujam
Journal: Proc Natl Acad Sci U S A Date: 2007-11-27 Impact factor: 11.205

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Authors: I Hassinen; B Chance
Journal: Biochem Biophys Res Commun Date: 1968-06-28 Impact factor: 3.575

Review 5. Mitochondrial oxidative stress: implications for cell death.

Authors: Sten Orrenius; Vladimir Gogvadze; Boris Zhivotovsky
Journal: Annu Rev Pharmacol Toxicol Date: 2007 Impact factor: 13.820

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Authors: A Puppi; M Dely
Journal: Acta Biol Hung Date: 1983

7. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Authors: Kaori Ishikawa; Keizo Takenaga; Miho Akimoto; Nobuko Koshikawa; Aya Yamaguchi; Hirotake Imanishi; Kazuto Nakada; Yoshio Honma; Jun-Ichi Hayashi
Journal: Science Date: 2008-04-03 Impact factor: 47.728

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Authors: Giovambattista Pani; Elisa Giannoni; Tommaso Galeotti; Paola Chiarugi
Journal: Antioxid Redox Signal Date: 2009-11 Impact factor: 8.401

Review 9. Redox control of protein conformation in flavoproteins.

Authors: Toshiya Senda; Miki Senda; Shigenobu Kimura; Tetsuo Ishida
Journal: Antioxid Redox Signal Date: 2009-07 Impact factor: 8.401

10. Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.

Authors: Sarah E Bohndiek; Mikko I Kettunen; De-en Hu; Brett W C Kennedy; Joan Boren; Ferdia A Gallagher; Kevin M Brindle
Journal: J Am Chem Soc Date: 2011-07-08 Impact factor: 15.419

21 in total

1. Optical redox imaging indices discriminate human breast cancer from normal tissues.

Authors: He N Xu; Julia Tchou; Min Feng; Huaqing Zhao; Lin Z Li
Journal: J Biomed Opt Date: 2016-11-01 Impact factor: 3.170

2. A pre-tracer approach for improving the accuracy of metabolic measurements by hyperpolarized nuclear magnetic resonance.

Authors: Lin Z Li
Journal: Quant Imaging Med Surg Date: 2016-10

3. Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond.

Authors: Weining Niu; Jun Wang; Jing Qian; Mengying Wang; Ping Wu; Fei Chen; Shasha Yan
Journal: J Biol Chem Date: 2018-01-03 Impact factor: 5.157

4. Wide-field optical spectroscopy system integrating reflectance and spatial frequency domain imaging to measure attenuation-corrected intrinsic tissue fluorescence in radical prostatectomy specimens.

Authors: Emile Beaulieu; Audrey Laurence; Mirela Birlea; Guillaume Sheehy; Leticia Angulo-Rodriguez; Mathieu Latour; Roula Albadine; Fred Saad; Dominique Trudel; Frédéric Leblond
Journal: Biomed Opt Express Date: 2020-03-17 Impact factor: 3.732

5. CHOP THERAPY INDUCED MITOCHONDRIAL REDOX STATE ALTERATION IN NON-HODGKIN'S LYMPHOMA XENOGRAFTS.

Authors: H N Xu; H Zhao; T A Mir; S C Lee; M Feng; R Choe; J D Glickson; L Z Li
Journal: J Innov Opt Health Sci Date: 2013-04

6. Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells.

Authors: Yu Wen; He N Xu; Lisa Privette Vinnedge; Min Feng; Lin Z Li
Journal: Mol Imaging Biol Date: 2019-06 Impact factor: 3.488