Literature DB >> 22892591

Unsolved problems in plastid transformation.

M Manuela Rigano1, Nunzia Scotti, Teodoro Cardi.   

Abstract

Plants have been proved as a novel production platform for a wide range of biologically important compounds such as enzymes, therapeutic proteins, antibiotics, and proteins with immunological properties. In this context, plastid genetic engineering can be potentially used to produce recombinant proteins. However, several challenges still remain to be overcome if the full potential of plastid transformation technology is to be realized. They include the development of plastid transformation systems for species other than tobacco, the expression of transgenes in non-green plastids, the increase of protein accumulation and the appearance of pleiotropic effects. In this paper, we discuss the novel tools recently developed to overcome some limitations of chloroplast transformation.

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Year:  2012        PMID： 22892591      PMCID： PMC3489708          DOI： 10.4161/bioe.21452

Source DB:  PubMed          Journal:  Bioengineered        ISSN： 2165-5979            Impact factor:   3.269


  30 in total

1.  An efficient downstream box fusion allows high-level accumulation of active bacterial beta-glucosidase in tobacco chloroplasts.

Authors:  Benjamin N Gray; Huijun Yang; Beth A Ahner; Maureen R Hanson
Journal:  Plant Mol Biol       Date:  2011-01-30       Impact factor: 4.076

Review 2.  Production of foreign proteins using plastid transformation.

Authors:  Nunzia Scotti; M Manuela Rigano; Teodoro Cardi
Journal:  Biotechnol Adv       Date:  2011-08-06       Impact factor: 14.227

Review 3.  Plastid biotechnology: food, fuel, and medicine for the 21st century.

Authors:  Pal Maliga; Ralph Bock
Journal:  Plant Physiol       Date:  2011-01-14       Impact factor: 8.340

4.  Transformation of alfalfa chloroplasts and expression of green fluorescent protein in a forage crop.

Authors:  Zhengyi Wei; Yanzhi Liu; Chunjing Lin; Yunpeng Wang; Qin'an Cai; Yingshan Dong; Shaochen Xing
Journal:  Biotechnol Lett       Date:  2011-07-23       Impact factor: 2.461

Review 5.  Chloroplast-derived vaccines against human diseases: achievements, challenges and scopes.

Authors:  Andreas G Lössl; Mohammad T Waheed
Journal:  Plant Biotechnol J       Date:  2011-03-29       Impact factor: 9.803

6.  Biolistic co-transformation of the nuclear and plastid genomes.

Authors:  Zouhair Elghabi; Stephanie Ruf; Ralph Bock
Journal:  Plant J       Date:  2011-06-24       Impact factor: 6.417

7.  A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule.

Authors:  Martin F Gisby; Philip Mellors; Panagiotis Madesis; Marianne Ellin; Hugh Laverty; Sharon O'Kane; Mark W J Ferguson; Anil Day
Journal:  Plant Biotechnol J       Date:  2011-04-27       Impact factor: 9.803

8.  A plant secretory signal peptide targets plastome-encoded recombinant proteins to the thylakoid membrane.

Authors:  Francesca De Marchis; Andrea Pompa; Roberta Mannucci; Tomas Morosinotto; Michele Bellucci
Journal:  Plant Mol Biol       Date:  2010-08-18       Impact factor: 4.076

9.  Plastid expression of a double-pentameric vaccine candidate containing human papillomavirus-16 L1 antigen fused with LTB as adjuvant: transplastomic plants show pleiotropic phenotypes.

Authors:  Mohammad T Waheed; Nadja Thönes; Martin Müller; Syed W Hassan; Johanna Gottschamel; Elke Lössl; Hans-Peter Kaul; Andreas G Lössl
Journal:  Plant Biotechnol J       Date:  2011-03-29       Impact factor: 9.803

10.  Metabolic adaptation in transplastomic plants massively accumulating recombinant proteins.

Authors:  Julia Bally; Claudette Job; Maya Belghazi; Dominique Job
Journal:  PLoS One       Date:  2011-09-22       Impact factor: 3.240
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  5 in total

1.  The HIV-1 Pr55 gag polyprotein binds to plastidial membranes and leads to severe impairment of chloroplast biogenesis and seedling lethality in transplastomic tobacco plants.

Authors:  N Scotti; L Sannino; A Idoine; P Hamman; A De Stradis; P Giorio; L Maréchal-Drouard; R Bock; T Cardi
Journal:  Transgenic Res       Date:  2014-10-29       Impact factor: 2.788

2.  The production of the first functional antibody mimetic in higher plants: the chloroplast makes the DARPin G3 for HER2 imaging in oncology.

Authors:  Maryam Ehsasatvatan; Bahram Baghban Kohnehrouz; Ashraf Gholizadeh; Hamideh Ofoghi; Dariush Shanehbandi
Journal:  Biol Res       Date:  2022-10-23       Impact factor: 7.634

Review 3.  Vitamin E Content and Composition in Tomato Fruits: Beneficial Roles and Bio-Fortification.

Authors:  Assunta Raiola; Gian Carlo Tenore; Amalia Barone; Luigi Frusciante; Maria Manuela Rigano
Journal:  Int J Mol Sci       Date:  2015-12-08       Impact factor: 5.923

4.  A built-in strategy to mitigate transgene spreading from genetically modified corn.

Authors:  Jing Li; Hui Yu; Fengzhen Zhang; Chaoyang Lin; Jianhua Gao; Jun Fang; Xiahui Ding; Zhicheng Shen; Xiaoli Xu
Journal:  PLoS One       Date:  2013-12-06       Impact factor: 3.240

5.  Building customizable auto-luminescent luciferase-based reporters in plants.

Authors:  Arjun Khakhar; Colby G Starker; James C Chamness; Nayoung Lee; Sydney Stokke; Cecily Wang; Ryan Swanson; Furva Rizvi; Takato Imaizumi; Daniel F Voytas
Journal:  Elife       Date:  2020-03-25       Impact factor: 8.140
  5 in total

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