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Literature DB >> 22892121

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.

Mark J Mitton-Fry¹, Joel T Arcari, Matthew F Brown, Jeffrey M Casavant, Steven M Finegan, Mark E Flanagan, Hongying Gao, David M George, Brian S Gerstenberger, Seungil Han, Joel R Hardink, Thomas M Harris, Thuy Hoang, Michael D Huband, Rebecca Irvine, Manjinder S Lall, M Megan Lemmon, Chao Li, Jian Lin, Sandra P McCurdy, John P Mueller, Lisa Mullins, Mark Niosi, Mark C Noe, David Pattavina, Joseph Penzien, Mark S Plummer, Hud Risley, Brandon P Schuff, Veerabahu Shanmugasundaram, Jeremy T Starr, Jianmin Sun, Jennifer Winton, Jennifer A Young.

Abstract

Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.

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Substances：

Year: 2012 PMID： 22892121 DOI： 10.1016/j.bmcl.2012.07.005

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

1. SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3.

Authors: Kerry E Murphy-Benenato; Brian Dangel; Hajnalka E Davis; Thomas F Durand-Réville; Andrew D Ferguson; Ning Gao; Haris Jahić; John P Mueller; Erika L Manyak; Olga Quiroga; Michael Rooney; Li Sha; Mark Sylvester; Frank Wu; Mark Zambrowski; Shannon X Zhao
Journal: ACS Med Chem Lett Date: 2015-03-22 Impact factor: 4.345

2. Influence of the α-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 β-Lactamase.

Authors: Michael D Sacco; Kyle G Kroeck; M Trent Kemp; Xiujun Zhang; Logan D Andrews; Yu Chen
Journal: Antimicrob Agents Chemother Date: 2019-12-20 Impact factor: 5.191

6. Preparation of 3-benzyloxy-2-pyridinone functional linkers: Tools for the synthesis of 3,2-hydroxypyridinone (HOPO) and HOPO/hydroxamic acid chelators.

Authors: Sarah Gibson; Rasika Fernando; Hollie K Jacobs; Aravamudan S Gopalan
Journal: Tetrahedron Date: 2015-12-08 Impact factor: 2.457

6 in total

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.

1. SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3.

2. Influence of the α-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 β-Lactamase.

Review 3. The evolving role of chemical synthesis in antibacterial drug discovery.

Review 4. New β-Lactamase Inhibitors in the Clinic.

5. Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3.

6. Preparation of 3-benzyloxy-2-pyridinone functional linkers: Tools for the synthesis of 3,2-hydroxypyridinone (HOPO) and HOPO/hydroxamic acid chelators.