BACKGROUND: MicroRNAs are proposed as plasma biomarkers in cancer. Glioblastoma is the most frequent primary brain tumor of adults. MicroRNA-21 was shown to induce glioblastoma growth. AIMS: To evaluate the circulating microRNA-21 in glioblastoma patients. METHODS: MicroRNA-21 copies in glioblastoma plasma (n = 10, before surgery and during/after concomitant chemoradiotherapy), control plasma (n = 10), and tissue samples were analyzed using RT-qPCR. RESULTS: MicroRNA-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). One patient with increasing microRNA-21 developed a histopathologically proven recurrence after the second sample collection. DISCUSSION: Circulating microRNA-21 might be a useful biomarker in glioblastoma.
BACKGROUND: MicroRNAs are proposed as plasma biomarkers in cancer. Glioblastoma is the most frequent primary brain tumor of adults. MicroRNA-21 was shown to induce glioblastoma growth. AIMS: To evaluate the circulating microRNA-21 in glioblastomapatients. METHODS:MicroRNA-21 copies in glioblastoma plasma (n = 10, before surgery and during/after concomitant chemoradiotherapy), control plasma (n = 10), and tissue samples were analyzed using RT-qPCR. RESULTS:MicroRNA-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). One patient with increasing microRNA-21 developed a histopathologically proven recurrence after the second sample collection. DISCUSSION: Circulating microRNA-21 might be a useful biomarker in glioblastoma.
Authors: Johan M Kros; Dana M Mustafa; Lennard J M Dekker; Peter A E Sillevis Smitt; Theo M Luider; Ping-Pin Zheng Journal: Neuro Oncol Date: 2014-09-24 Impact factor: 12.300
Authors: Yirizhati Aili; Nuersimanguli Maimaitiming; Yusufu Mahemuti; Hu Qin; Yongxin Wang; Zengliang Wang Journal: Am J Cancer Res Date: 2020-12-01 Impact factor: 6.166
Authors: Zammam Areeb; Stanley S Stylli; Rachel Koldej; David S Ritchie; Tali Siegal; Andrew P Morokoff; Andrew H Kaye; Rodney B Luwor Journal: J Neurooncol Date: 2015-09-21 Impact factor: 4.130