Literature DB >> 22891619

Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.

Suwei Dong1, Shiying Shang, Jianfeng Li, Zhongping Tan, Thomas Dean, Akira Maeda, Thomas J Gardella, Samuel J Danishefsky.   

Abstract

Application of chemical synthesis to gain access to high purity hPTH as well as more stable analogues was accomplished through a menu of extended NCL followed by metal free dethiylation.

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Year:  2012        PMID： 22891619      PMCID： PMC3462362          DOI： 10.1021/ja306637u

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  55 in total

1.  Covalent capture: a new tool for the purification of synthetic and recombinant polypeptides.

Authors:  M Villain; J Vizzavona; K Rose
Journal:  Chem Biol       Date:  2001-07

2.  Total synthesis of the α-subunit of human glycoprotein hormones: toward fully synthetic homogeneous human follicle-stimulating hormone.

Authors:  Baptiste Aussedat; Bernhard Fasching; Eric Johnston; Neeraj Sane; Pavel Nagorny; Samuel J Danishefsky
Journal:  J Am Chem Soc       Date:  2012-02-06       Impact factor: 15.419

3.  Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides.

Authors:  Qian Wan; Samuel J Danishefsky
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

4.  Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization.

Authors:  S Li; C Schöneich; R T Borchardt
Journal:  Biotechnol Bioeng       Date:  1995-12-05       Impact factor: 4.530

5.  Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis.

Authors:  Jin Chen; Qian Wan; Yu Yuan; Jianglong Zhu; Samuel J Danishefsky
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

6.  Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations.

Authors:  Thomas Dean; Agnes Linglart; Matthew J Mahon; Murat Bastepe; Harald Jüppner; John T Potts; Thomas J Gardella
Journal:  Mol Endocrinol       Date:  2005-12-08

7.  Oxidation of recombinant human parathyroid hormone: effect of oxidized position on the biological activity.

Authors:  Y Nabuchi; E Fujiwara; K Ueno; H Kuboniwa; Y Asoh; H Ushio
Journal:  Pharm Res       Date:  1995-12       Impact factor: 4.200

8.  An advance in proline ligation.

Authors:  Shiying Shang; Zhongping Tan; Suwei Dong; Samuel J Danishefsky
Journal:  J Am Chem Soc       Date:  2011-06-23       Impact factor: 15.419

9.  Probing the stability of nonglycosylated wild-type erythropoietin protein via reiterative alanine ligations.

Authors:  John A Brailsford; Samuel J Danishefsky
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-12       Impact factor: 11.205

10.  Methionine oxidation in human growth hormone and human chorionic somatomammotropin. Effects on receptor binding and biological activities.

Authors:  L C Teh; L J Murphy; N L Huq; A S Surus; H G Friesen; L Lazarus; G E Chapman
Journal:  J Biol Chem       Date:  1987-05-15       Impact factor: 5.157
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  6 in total

1.  At last: erythropoietin as a single glycoform.

Authors:  Ping Wang; Suwei Dong; John A Brailsford; Karthik Iyer; Steven D Townsend; Qiang Zhang; Ronald C Hendrickson; JaeHung Shieh; Malcolm A S Moore; Samuel J Danishefsky
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-25       Impact factor: 15.336

Review 2.  Total synthesis of glycosylated proteins.

Authors:  Alberto Fernández-Tejada; John Brailsford; Qiang Zhang; Jae-Hung Shieh; Malcolm A S Moore; Samuel J Danishefsky
Journal:  Top Curr Chem       Date:  2015

Review 3.  International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.

Authors:  Thomas J Gardella; Jean-Pierre Vilardaga
Journal:  Pharmacol Rev       Date:  2015       Impact factor: 25.468

Review 4.  The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last.

Authors:  Rebecca M Wilson; Suwei Dong; Ping Wang; Samuel J Danishefsky
Journal:  Angew Chem Int Ed Engl       Date:  2013-06-17       Impact factor: 15.336

5.  Traceless β-mercaptan-assisted activation of valinyl benzimidazolinones in peptide ligations.

Authors:  Yinglu Wang; Lin Han; Ning Yuan; Hanxuan Wang; Hongxing Li; Jinrong Liu; Huan Chen; Qiang Zhang; Suwei Dong
Journal:  Chem Sci       Date:  2018-01-05       Impact factor: 9.825

6.  Diazonium-Modified Screen-Printed Electrodes for Immunosensing Growth Hormone in Blood Samples.

Authors:  Nan Li; Ari M Chow; Hashwin V S Ganesh; Melanie Ratnam; Ian R Brown; Kagan Kerman
Journal:  Biosensors (Basel)       Date:  2019-07-17
  6 in total

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