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Literature DB >> 22890975

Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms.

Nicolas Barraud¹, Bharat G Kardak, Nageshwar R Yepuri, Robert P Howlin, Jeremy S Webb, Saul N Faust, Staffan Kjelleberg, Scott A Rice, Michael J Kelso.

Abstract

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication.

Entities: Chemical Species

Mesh：

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Year: 2012 PMID： 22890975 DOI： 10.1002/anie.201202414

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

34 in total

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Review 2. Targeting microbial biofilms: current and prospective therapeutic strategies.

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3. Low Concentrations of Nitric Oxide Modulate Streptococcus pneumoniae Biofilm Metabolism and Antibiotic Tolerance.

Authors: Raymond N Allan; Samantha Morgan; Sanjita Brito-Mutunayagam; Paul Skipp; Martin Feelisch; Stephen M Hayes; William Hellier; Stuart C Clarke; Paul Stoodley; Andrea Burgess; Hasnaa Ismail-Koch; Rami J Salib; Jeremy S Webb; Saul N Faust; Luanne Hall-Stoodley
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4. Discovery of Two Bacterial Nitric Oxide-Responsive Proteins and Their Roles in Bacterial Biofilm Regulation.

Authors: Sajjad Hossain; Lisa-Marie Nisbett; Elizabeth M Boon
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5. Cephalosporin-3'-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms.

Authors: Samuel A Collins; Michael J Kelso; Ardeshir Rineh; Nageshwar R Yepuri; Janice Coles; Claire L Jackson; Georgia D Halladay; Woolf T Walker; Jeremy S Webb; Luanne Hall-Stoodley; Gary J Connett; Martin Feelisch; Saul N Faust; Jane S A Lucas; Raymond N Allan
Journal: Antimicrob Agents Chemother Date: 2017-01-24 Impact factor: 5.191

Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms.

Review 1. Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy.

Review 2. Targeting microbial biofilms: current and prospective therapeutic strategies.

3. Low Concentrations of Nitric Oxide Modulate Streptococcus pneumoniae Biofilm Metabolism and Antibiotic Tolerance.

4. Discovery of Two Bacterial Nitric Oxide-Responsive Proteins and Their Roles in Bacterial Biofilm Regulation.

5. Cephalosporin-3'-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms.

Review 6. Nitric Oxide-Releasing Macromolecular Scaffolds for Antibacterial Applications.

7. Progress towards a stable cephalosporin-halogenated phenazine conjugate for antibacterial prodrug applications.

Review 8. Origin and Impact of Nitric Oxide in Pseudomonas aeruginosa Biofilms.

Review 9. Controlling biofilms using synthetic biology approaches.

10. Eradicating uropathogenic Escherichia coli biofilms with a ciprofloxacin-dinitroxide conjugate.