Literature DB >> 22890627

Facile synthesis of sterically hindered and electron-deficient secondary amides from isocyanates.

Gabriel Schäfer1, Coraline Matthey, Jeffrey W Bode.   

Abstract

The big easy: The direct coupling of Grignard reagents to isocyanates provides a facile and robust solution for the synthesis of sterically hindered and electron-deficient secondary amides. The products are obtained in high yields without the need for excess reagents or chromatographic purification.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22890627     DOI： 10.1002/anie.201204481

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  11 in total

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