Literature DB >> 22889868

Right heart failure in the intensive care unit.

Clifford R Greyson1.   

Abstract

PURPOSE OF REVIEW: This review summarizes the approach to and recent developments in the evaluation and treatment of acute right heart failure in the ICU. Right heart failure, defined as failure of the right ventricle to provide sufficient blood flow through the pulmonary circulation at normal central venous pressure, is a common problem caused by a combination of increased right-ventricular afterload and right-ventricular contractile dysfunction. RECENT
FINDINGS: Management of acute right heart failure continues to be challenging because of insufficient understanding of its pathophysiology, a lack of guidelines, and few available tools. Recent research has contributed to an improved understanding of its mechanisms, helping to guide therapy and suggest future options. Right-ventricular assist devices are emerging as a promising approach to treatment when optimization of hemodynamics and conventional medical therapy fail.
SUMMARY: Right heart failure causes venous congestion and systemic hypoperfusion. Once right heart failure is identified, the primary goal is to alleviate any reversible cause of excessive load or right-ventricular contractile failure. When the underlying abnormalities cannot be alleviated, trials of diuretic, vasodilator, or inotropic therapy may be required. Invasive monitoring helps guide therapy. Medically refractory right heart failure may potentially be treated with right-ventricular assist devices.

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Year:  2012        PMID: 22889868     DOI: 10.1097/MCC.0b013e3283577070

Source DB:  PubMed          Journal:  Curr Opin Crit Care        ISSN: 1070-5295            Impact factor:   3.687


  4 in total

Review 1.  Acute right heart syndrome in the critically ill patient.

Authors:  V Zochios; N Jones
Journal:  Heart Lung Vessel       Date:  2014

2.  Effect of positive end-expiratory pressure on porcine right ventricle function assessed by speckle tracking echocardiography.

Authors:  Sam R Orde; Atta Behfar; Paul G Stalboerger; Sergio Barros-Gomes; Garvan C Kane; Jae K Oh
Journal:  BMC Anesthesiol       Date:  2015-04-11       Impact factor: 2.217

3.  A pig model of acute right ventricular afterload increase by hypoxic pulmonary vasoconstriction.

Authors:  Kathrine Knai; Nils Kristian Skjaervold
Journal:  BMC Res Notes       Date:  2017-01-03

4.  Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism.

Authors:  Evandro M Neto-Neves; Ozelia Sousa-Santos; Karina C Ferraz; Elen Rizzi; Carla S Ceron; Minna M D Romano; Luis G Gali; Benedito C Maciel; Richard Schulz; Raquel F Gerlach; Jose E Tanus-Santos
Journal:  J Cell Mol Med       Date:  2013-11-06       Impact factor: 5.310

  4 in total

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