AIM: Perineal wound sepsis is a common problem after abdominoperineal resection of the rectum (APR), with a reported incidence of 10-15% in previously non-irradiated patients, 20-30% in patients given preoperative radiation and 50% among patients submitted to preoperative radiation combined with chemotherapy. The local application of gentamicin-collagen was evaluated to determine whether its use in the perineal wound reduced risk complications and had an effect on cancer recurrence. METHOD: In this prospective multicentre (seven hospitals) randomized controlled trial, 102 patients undergoing APR due to cancer or benign disease were randomized into two groups including surgery with gentamicin-collagen (GS+, n = 52) or surgery without gentamicin-collagen (GS-, n = 50). Patients were followed at 7, 30 and 90 days and at 1 and 5 years. RESULTS: There were no statistically significant differences between the two groups regarding perineal wound complications, infectious or non-infectious, or cancer recurrence. CONCLUSION: There was no statistically significant effect on perineal wound complications or cancer recurrence following the local administration of gentamicin-collagen during APR.
RCT Entities:
AIM: Perineal wound sepsis is a common problem after abdominoperineal resection of the rectum (APR), with a reported incidence of 10-15% in previously non-irradiated patients, 20-30% in patients given preoperative radiation and 50% among patients submitted to preoperative radiation combined with chemotherapy. The local application of gentamicin-collagen was evaluated to determine whether its use in the perineal wound reduced risk complications and had an effect on cancer recurrence. METHOD: In this prospective multicentre (seven hospitals) randomized controlled trial, 102 patients undergoing APR due to cancer or benign disease were randomized into two groups including surgery with gentamicin-collagen (GS+, n = 52) or surgery without gentamicin-collagen (GS-, n = 50). Patients were followed at 7, 30 and 90 days and at 1 and 5 years. RESULTS: There were no statistically significant differences between the two groups regarding perineal wound complications, infectious or non-infectious, or cancer recurrence. CONCLUSION: There was no statistically significant effect on perineal wound complications or cancer recurrence following the local administration of gentamicin-collagen during APR.
Authors: R L Nelson; N M Iqbal; A Kravets; R Khateeb; M Raza; M Siddiqui; I Taha; A Tummala; R Epple; S Huang; M Wen Journal: Tech Coloproctol Date: 2018-07-17 Impact factor: 3.781
Authors: Andrzej Rutkowski; Lucyna Pietrzak; Jacek Kryński; Leszek Zając; Mariusz Bednarczyk; Tomasz Olesiński; Marek Szpakowski; Piotr Saramak; Ireneusz Pierzankowski; Piotr Hevelke; Piotr Surowski; Krzysztof Bujko Journal: Int J Colorectal Dis Date: 2018-04-15 Impact factor: 2.571
Authors: A Rutkowski; L Zając; L Pietrzak; M Bednarczyk; A Byszek; J Oledzki; T Olesiński; M Szpakowski; P Saramak; M Chwalinski Journal: Tech Coloproctol Date: 2014-07-04 Impact factor: 3.781