Brain water content. A misunderstood measurement?

Brain edema is a major contributor to poor outcome following ischemic and hemorrhagic stroke. In animal models, edema has historically been quantified as a change in % brain water content (water content/wet weight). As described in this communication, this number can be misleading, as 'small' changes in % brain water content actually reflect much bigger changes in brain swelling. Using either water content, expressed as g/g dry weight, or a measure of brain swelling, better reflect the impact of edema after stroke and brain injury.