Literature DB >> 2288768

Inhibition of fatty acid-supported mitochondrial respiration by cyclosporine.

C A Lemmi1, R L Miller, J Rajfer.   

Abstract

We have shown that, in addition to inhibition of the succinate-supported energy pathway (5), CS inhibition of mitochondrial Complex II activity also limits fatty acid oxidation. These results are consistent with the participation of altered lipid metabolism in CS nephrotoxicity.

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Year:  1990        PMID: 2288768     DOI: 10.1016/0885-4505(90)90071-8

Source DB:  PubMed          Journal:  Biochem Med Metab Biol        ISSN: 0885-4505


  1 in total

1.  Effect of cyclosporin A and its vehicle on cardiac and skeletal muscle mitochondria: relationship to efficacy of the respiratory chain.

Authors:  H Sanchez; J Zoll; X Bigard; V Veksler; B Mettauer; E Lampert; J Lonsdorfer; R Ventura-Clapier
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

  1 in total

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