Literature DB >> 22887437

Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.

J P Michael Motion1, Juliane Nguyen, Francis C Szoka.   

Abstract

License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase-triggered approach may be useful to create target-specific lipid nanocarriers.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22887437      PMCID： PMC3470804          DOI： 10.1002/anie.201204198

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  38 in total

1.  Membrane interactions of the synthetic N-terminal peptide of HIV-1 gp41 and its structural analogs.

Authors:  P W Mobley; A J Waring; M A Sherman; L M Gordon
Journal:  Biochim Biophys Acta       Date:  1999-04-14

Review 2.  From promiscuity to precision: protein phosphatases get a makeover.

Authors:  David M Virshup; Shirish Shenolikar
Journal:  Mol Cell       Date:  2009-03-13       Impact factor: 17.970

3.  The fusion peptide domain is the primary membrane-inserted region and enhances membrane interaction of the ectodomain of HIV-1 gp41.

Authors:  Shu-Fang Cheng; Miao-Ping Chien; Chi-Hui Lin; Chung-Chieh Chang; Chun-Hung Lin; Yu-Tsan Liu; Ding-Kwo Chang
Journal:  Mol Membr Biol       Date:  2010-01       Impact factor: 2.857

4.  Prostatic specific antigen and prostatic acid phosphatase in the monitoring and staging of patients with prostatic cancer.

Authors:  C J Ercole; P H Lange; M Mathisen; R K Chiou; P K Reddy; R L Vessella
Journal:  J Urol       Date:  1987-11       Impact factor: 7.450

5.  Differential sensitivity of human prostatic cancer cell lines to the effects of protein kinase and phosphatase inhibitors.

Authors:  O W Rokhlin; M B Cohen
Journal:  Cancer Lett       Date:  1995-11-27       Impact factor: 8.679

6.  Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture.

Authors:  C J Chu; J Dijkstra; M Z Lai; K Hong; F C Szoka
Journal:  Pharm Res       Date:  1990-08       Impact factor: 4.200

7.  Targeting and penetration of virus receptor bearing cells by nanoparticles coated with envelope proteins of Moloney murine leukemia virus.

Authors:  Drew C Deniger; Andrey A Kolokoltsov; Andrew C Moore; Thomas B Albrecht; Robert A Davey
Journal:  Nano Lett       Date:  2006-11       Impact factor: 11.189

8.  Tartrate-resistant acid phosphatase as a diagnostic factor for arthritis.

Authors:  Jae-Won Seol; Hae-Beom Lee; Nam-Soo Kim; Sang-Youel Park
Journal:  Int J Mol Med       Date:  2009-07       Impact factor: 4.101

9.  PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes.

Authors:  Qin Yang; Stine K Larsen; Zhibao Mi; Paul D Robbins; Per H Basse
Journal:  AAPS J       Date:  2008-12-23       Impact factor: 4.009

Review 10.  Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics.

Authors:  Frederic Heitz; May Catherine Morris; Gilles Divita
Journal:  Br J Pharmacol       Date:  2009-03-20       Impact factor: 8.739
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  3 in total

1.  Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide.

Authors:  Misao Akishiba; Toshihide Takeuchi; Yoshimasa Kawaguchi; Kentarou Sakamoto; Hao-Hsin Yu; Ikuhiko Nakase; Tomoka Takatani-Nakase; Fatemeh Madani; Astrid Gräslund; Shiroh Futaki
Journal:  Nat Chem       Date:  2017-05-22       Impact factor: 24.427

2.  The availability of drug by liposomal drug delivery : Individual kinetics and tissue distribution of encapsulated and released drug in mice after administration of PEGylated liposomal prednisolone phosphate.

Authors:  Evelien A W Smits; José A Soetekouw; Ebel H E Pieters; Coen J P Smits; Nicolette de Wijs-Rot; Herman Vromans
Journal:  Invest New Drugs       Date:  2018-12-13       Impact factor: 3.850

3.  The fluorination effect of fluoroamphiphiles in cytosolic protein delivery.

Authors:  Zhenjing Zhang; Wanwan Shen; Jing Ling; Yang Yan; Jingjing Hu; Yiyun Cheng
Journal:  Nat Commun       Date:  2018-04-10       Impact factor: 14.919
  3 in total

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